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首页> 外文期刊>Neurobiology of learning and memory >Orexin 1 and orexin 2 receptor antagonism in the basolateral amygdala modulate long-term potentiation of the population spike in the perforant path-dentate gyrus-evoked field potential in rats
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Orexin 1 and orexin 2 receptor antagonism in the basolateral amygdala modulate long-term potentiation of the population spike in the perforant path-dentate gyrus-evoked field potential in rats

机译：orexin 1和orexin 2受体拮抗拮抗症在基石运动amygdala调节人口刺激的长期增强在大鼠的穿孔路径诱发的鸟类潜力中

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Involvement of amygdalo-hippocampal substructures in patients with narcolepsy due to deficiencies in the orexinergic system, and the presence of hippocampus-dependent memory impairments in this disorder, have led us to investigate the effects of orexin 1 and 2 receptor antagonism in the basolateral amygdala (BLA) on long-term potentiation (LTP) of dentate gyrus (DG) granular cells. We used a 200-Hz high-frequency stimulation protocol in anesthetized rats. We studied the long-term synaptic plasticity of perforant path-dentate gyrus granule cells following the inactivation of orexin receptors before and after tetanic stimulation. LTP of the DG population spike was attenuated in the presence of orexin 1 and 2 receptor antagonism (treatment with SB-334867-A and TCS-OX2-29, respectively) in the BLA when compared to that observed following treatment with dimethyl sulfoxide (DMSO). However, the population excitatory post-synaptic potentials were not affected. Moreover, when orexin 1 and 2 receptors in the BLA were blocked after LTP induction, there were no differences between the DMSO and treatment groups. Our findings suggest that the orexinergic system of the BLA plays a modulatory role in the regulation of hippocampal plasticity in rats.
机译：Amygdalo-hippampAl子结构在鼻腔Pepsy患者患者中引起的癌症能力缺陷，以及在这种疾病中的海马依赖记忆障碍的存在，导致我们研究了orexin 1和2受体拮抗作用在基底外侧杏仁醛（ BLA）在牙齿过度（DG）颗粒细胞的长期增强（LTP）上。我们在麻醉大鼠中使用了200 Hz的高频刺激方案。在滴定蛋白受体之前和之后，研究了滴答蛋白受体前后的穿孔路径牙齿颗粒细胞的长期突触可塑性。与用二甲基砜（DMSO）处理相比，在BLA中，在BLA中的存在（分别用SB-334867-A和TCS-OX2-29处理）衰减DG种群峰值的LTP。 ）。然而，人口兴奋性突触后潜力不受影响。此外，当在LTP诱导之后阻断BLA中的orexin 1和2受体时，DMSO和治疗组之间没有差异。我们的研究结果表明，BLA的orexinergics系统在大鼠海马可塑性调节中发挥了调节作用。

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