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首页> 外文期刊>Neurobiology of learning and memory >Absence of fear renewal and functional connections between prefrontal cortex and hippocampus in infant mice
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Absence of fear renewal and functional connections between prefrontal cortex and hippocampus in infant mice

机译：婴儿小鼠前额叶皮质和海马之间没有恐惧更新和功能联系

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Impairment in fear extinction is widely viewed as a major contributor to, or even an underlying mechanism of, the pathogenesis of anxiety disorders and PTSD. Children with traumatic experience have a higher risk for developing anxiety disorders and PTSD in the adult. Little is known about the nature of fear memory extinction and its underlying mechanism during this period. Here we showed that while renewal of fear memory is context-specific in adult mice, it is absent in infant mice (P17). Using local injection of GABAa receptor antagonist picrotoxin, we found that there is no functional connectivity between infralimbic prefrontal cortex and hippo-campus in P17 mice, while prefrontal cortex projection to amygdala is functioning. Hence, the lack of fear renewal is likely caused by the lack of connections between hippocampus and prefrontal cortex which are known to be involved in the regulation of extinction memory.
机译：恐惧灭绝的减值被广泛地被视为焦虑症和应激障碍发病机制的主要贡献者甚至是疾病疾病发病机制。 具有创伤体验的儿童在成年人中发育焦虑症和应激障碍的风险较高。 在此期间，关于恐惧记忆灭绝的性质及其潜在机制的本质知之甚少。 在这里，我们表明，在恐惧记忆的更新时是成年小鼠的上下文特异性，但它在婴儿小鼠中不存在（P17）。 使用局部注射GABAA受体拮抗剂的野生毒素，我们发现在P17小鼠中没有内毛细的前额叶皮质和河马校区之间没有功能性连接，而前额叶皮质投影到Amygdala正在运作。 因此，缺乏恐惧更新可能是由于海马和前额叶皮质之间缺乏连接而导致的，这已知是参与消光记忆的调节。

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