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首页> 外文期刊>Neurobiology of learning and memory >Learning what to expect and when to expect it involves dissociable neural systems
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Learning what to expect and when to expect it involves dissociable neural systems

机译：学习预期和何时期望它涉及可解释的神经系统

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Two experiments with Long-Evans rats examined the potential independence of learning about different features of food reward, namely, "what" reward is to be expected and "when" it will occur. This was examined by investigating the effects of selective reward devaluation upon responding in an instrumental peak timing task in Experiment 1 and by exploring the effects of pre-training lesions targeting the basolateral amygdala (BLA) upon the selective reward devaluation effect and interval timing in a Pavlovian peak timing task in Experiment 2. In both tasks, two stimuli, each 60 s long, signaled that qualitatively distinct rewards (different flavored food pellets) could occur after 20 s. Responding on non-rewarded probe trials displayed the characteristic peak timing function with mean responding gradually increasing and peaking at approximately 20 s before more gradually declining thereafter. One of the rewards was then independently paired repeatedly with LiCl injections in order to devalue it whereas the other reward was unpaired with these injections. In a final set of test sessions in which both stimuli were presented without rewards, it was observed that responding was selectively reduced in the presence of the stimulus signaling the devalued reward compared to the stimulus signaling the still valued reward. Moreover, the timing function was mostly unaltered by this devaluation manipulation. Experiment 2 showed that pre-training BLA lesions abolished this selective reward devaluation effect, but it had no impact on peak timing functions shown by the two stimuli. It appears from these data that learning about "what" and "when" features of reward may entail separate underlying neural systems.
机译：长埃文斯大鼠的两项实验审查了学习对食物奖励不同特征的潜在独立性，即“预期的”奖励是什么“奖励”。通过调查选择性奖励贬值在实验1中的乐器峰时序任务中的乐观峰时任务时以及探索靶向奖励贬值效果和间隔时机的训练病变的影响，研究了选择性奖励贬值实验中的Pavlovian峰时序任务2.在两个任务中，两个刺激，每60秒，信号都可以在20秒后发生定性不同的奖励（不同的味道食物颗粒）。响应非奖励探针试验显示特征峰正时功能，平均响应响应在大约20秒之前逐渐增加和达到峰值，此后更逐渐下降。然后，其中一个奖励与LiCl注射一起独立配对，以便将其贬值，而其他奖励是对这些注射的不配对。在没有奖励的情况下呈现两个刺激的最后一组测试会话中，观察到，与仍然有价值的奖励的刺激相比，在刺激的存在下，在刺激的存在下，选择性地减少了响应。此外，定时函数大多由这种贬值操作不妨碍。实验2显示预先训练的BLA病变废除了这种选择性奖励贬值效应，但它对两种刺激所示的峰定时功能没有影响。从这些数据中出现了学习“什么”和“当”奖励的特征可能需要单独的底层神经系统。

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