...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurobiology of learning and memory >Neural plasticity is modified over the human menstrual cycle: Combined insight from sensory evoked potential LTP and repetition suppression
【24h】

Neural plasticity is modified over the human menstrual cycle: Combined insight from sensory evoked potential LTP and repetition suppression

机译：在人体月经周期中修饰神经可塑性：感觉诱发潜在的LTP和重复抑制的综合洞察力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In healthy women, fluctuations in hormones including progesterone and oestradiol lead to functional changes in the brain over the course of each menstrual cycle. Though considerable attention has been directed towards understanding changes in human cognition over the menstrual cycle, changes in underlying processes such as neural plasticity have largely only been studied in animals. In this study we explored predictive coding and repetition suppression via the roving mismatch negativity paradigm as a model of short-term plasticity (Garrido, Kilner, Kiebel, et al., 2009), and Hebbian learning via visual sensory long-term potentiation (LTP) as a model of long-term plasticity (Teyler et al., 2005). Electroencephalography (EEG) was recorded in 20 females during their early follicular and mid-luteal phases. Event-related potential (ERP) analyses were complemented with dynamic causal modelling (DCM) to characterise changes in the underlying neural architecture. More sustained variability in the ERP response to a change in tone during the luteal phase are interpreted as a delayed habituation of the P3a component in the luteal relative to the follicular phase. The additional increased forward connection strength over tone repetitions compared to the follicular phase suggests that, in this phase, females may be less efficient when processing deviations from predicted sensory input (error). In contrast, there appears to be no reliable change in sensory LTP. This suggests that predictive coding, but not Hebbian plasticity is modified in the mid-luteal compared to the follicular phase, at least at the days of the menstrual cycle tested. This finding implicates the human menstrual cycle in complex changes in neural plasticity and provides further evidence for the importance of considering the menstrual cycle when including females in electrophysiological research.
机译：在健康的女性中，在每个月经周期的过程中，激素在包括孕激素和雌二醇的激素波动导致大脑的功能变化。虽然对月经周期的理解人类认知的变化是相当大的关注，但在动物中仅研究了神经可塑性等潜在过程的变化。在这项研究中，我们通过漫游错配的消极范式作为短期可塑性模型（Garrido，Kilner，Kiebel，等，2009），通过视觉感官长期增强（LTP ）作为长期可塑性的模型（Teyler等，2005）。在早期滤泡和中生阶段期间，脑电图（EEG）被记录在20名女性中。与事件相关的潜在（ERP）分析与动态因果建模（DCM）互补，以表征底层神经结构的变化。 ERP对肺癌期间对音调变化的ERP反应的更持续可变性被解释为Luteal中P3A组分相对于滤色相的延迟习惯。与彩色阶段相比，对音调重复的额外增加的前进连接强度表明，在该阶段，当处理与预测的感觉输入（误差）的偏差时，女性可能较低。相比之下，感觉LTP似乎没有可靠的变化。这表明预测性编码，但与卵泡相比，在中滞后，至少在月经周期的日子中，在中脑中修饰了Hebbian可塑性。这种发现暗示了人的月经周期在神经可塑性的复杂变化中，并提供了在电生理学研究中包括女性在内的女性时考虑月经周期的重要性的进一步证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号