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首页> 外文期刊>Neurogastroenterology and motility >Chicago Classification normative metrics in a healthy Indian cohort for a 16‐channel water‐perfused high‐resolution esophageal manometry system
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Chicago Classification normative metrics in a healthy Indian cohort for a 16‐channel water‐perfused high‐resolution esophageal manometry system

机译：芝加哥对健康印度队列的芝加哥分类规范度量为16通道水灌注的高分辨率食管测压系统

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Abstract Background High‐resolution esophageal manometry ( HREM ) interpretation by the Chicago Classification ( CC ) derives its normal values from western volunteers using solid‐state catheters. There is no normative data for the 16‐channel water‐perfused HREM system commonly used in India. Aims To determine normal values for a 16‐channel water‐perfused HREM catheter in supine posture using healthy volunteers and substitute these normal values (if different from CC values) in the CC v3.0 algorithm. Methods After ethics approval and informed consent, 53 volunteers (31 men) with no gastrointestinal ( GI ) symptoms or medications affecting GI motility underwent HREM by standard protocol. Age, gender, body mass index ( BMI ), and manometry parameters analyzed using Trace 1.3.3 software were collected. The median, range, and 5, 10, 75, and 95 percentiles (where applicable) were obtained for all HREM metrics. Normal value percentiles were defined as 95th (integrated relaxation pressure [IRP]), 10th‐100th (distal contractile integral [DCI]), and minimum (distal latency [DL]). Results The mean age was 30?years and the BMI was 24.2?kg?m ?2 . Compared to CC , our normal metrics were lower for IRP (13?mm Hg) and DCI (350‐4500?mm Hg?s?cm). DCI 4500 and 70 (5th percentile) were defined as hypercontractile and failed contraction, respectively. Abnormal DL (4.5?s) and peristaltic break size (5?cm) were similar to CC metrics. Applying these metrics, CC diagnoses changed in 15% (8/53) with downgrading of ineffective motility to fragmented peristalsis or normal, due to lower DCI cutoff used. Conclusions This is the first report of normative data for the 16‐channel water‐perfused system in supine posture. It revealed lower IRP and DCI , necessitating modification of CC cutoffs for this system.
机译：摘要背景技术芝加哥分类（CC）的高分辨率食管测量法（HREM）解释（CC）通过使用固态导管来源于西方志愿者的正常价值。在印度通常使用的16通道水灌注HREM系统没有规范数据。旨在使用健康志愿者在仰卧姿势中确定16通道水灌注的HREM导管的正常值，并在CC V3.0算法中替换这些正常值（如果与CC值不同）。方法伦理批准和知情同意，53名志愿者（31人）没有胃肠道（GI）症状或药物影响GI运动的标准方案。收集了使用Trace 1.3.3软件分析的年龄，性别，体重指数（BMI）和测测参数。为所有HREM度量获得中位数，范围和5,10,75和95个百分位数（适用）。正常值百分比定义为95级（集成弛豫压力[IRP]），10-100（远端收缩积分[DCI]）和最小（远端延迟[DL]）。结果平均年龄为30？年龄，BMI是24.2？kg？m？2。与CC相比，IRP（13毫米）和DCI（350-4500？MMHG≤C2），我们的正常度量较低。 DCI＆ 4500和70（＆ 70（＆ 5百分位数）分别定义为过度透明和失败的收缩。异常DL（＆ 4.5·s）和蠕动断裂尺寸（＆ 5？cm）与CC度量相似。应用这些指标，CC诊断在15％（8/53）中发生变化，因使用较低的DCI截止而降低了碎裂的蠕动或正常的折衷动力。结论这是仰卧姿势的16通道水灌注系统的第一份规范数据的报告。它揭示了较低的IRP和DCI，需要修改该系统的CC截止值。

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