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首页> 外文期刊>Neurogastroenterology and motility >Effect of electrode separation on high‐resolution impedance manometry catheters for ex vivo animal experiments
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Effect of electrode separation on high‐resolution impedance manometry catheters for ex vivo animal experiments

机译：电极分离对前体内动物实验的高分辨率阻抗测压导尿管的影响

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Abstract Background High‐resolution impedance manometry (HRIM) catheters are used for esophageal reflux and bolus transit studies. Usually, these catheters have electrodes spaced at 20?mm intervals that are used for measuring electrical impedance between the consecutive electrodes and pressure sensors with 10?mm separation. Electrical impedance is a distributed measurement between the electrodes, unlike the point measurement of pressure sensors. Thus, the electrode separations affect the overall spatiotemporal resolution of the measurement. Methods A 3D model of the gastrointestinal tract, in which bolus shape and size can be modified, was used to simulate the admittance signal response of an intraluminal impedance catheter with 10 and 20?mm electrode separation to study the distributed sensitivity in the lumen to gain insight on the impedance measurement. In addition, experiments on sections of rabbit proximal colon were conducted with two catheters with electrode separations of 10 and 20?mm to compare the experimental data with the simulated data. Key Results Reducing electrode spacing from 20 to 10?mm increased sensitivity to diameter change by a factor of ten. Admittance and diameter correlated strongly during a myogenic contraction with a Pearson's Correlation Coefficient of 0.86 for the custom catheter, in comparison with 0.56 for the commercial HRIM catheter. Conclusions Ten millimeter electrode separation has a better spatiotemporal resolution, and unlike 20?mm electrode separation is able to identify myogenic contractions. Based on the numerical and experimental data, closer electrode separation should be considered for improved spatial resolution.
机译：摘要背景高分辨率阻抗测压器（HRIM）导管用于食管反流和推注运输研究。通常，这些导管具有以20Ωmm间隔开的电极，其用于测量连续电极和具有10Ω分离的压力传感器之间的电阻抗。与压力传感器的点测量不同，电阻抗是电极之间的分布式测量。因此，电极分离会影响测量的总时空分辨率。方法采用胃肠道的3D模型，其中可以改变推注形状和尺寸，用于模拟腔内阻抗导管的导入信号响应，电极分离，以研究腔内的分布式灵敏度洞察阻抗测量。此外，在兔近端结肠切片的实验用两个导管进行，电极分离为10和20Ωmm，以将实验数据与模拟数据进行比较。关键结果减少20至10Ωmm的电极间距增加到直径变化的敏感性十倍。与商业HRIM导管的0.56相比，在肌原遗传学期间与Pearonon的相关系数为0.86的Pearon的相关系数，导纳和直径强烈相关。结论10毫米电极分离具有更好的时空分辨率，并且与20？mm电极分离不同能够识别肌遗传学收缩。基于数值和实验数据，应考虑更接近的电极分离以改善空间分辨率。

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