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首页> 外文期刊>Neurological Research: An Interdisciplinary Quarterly Journal >Correlation between risk factors of cerebrovascular disease and calcified plaque characteristics in patients with atherosclerotic severe carotid stenosis
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Correlation between risk factors of cerebrovascular disease and calcified plaque characteristics in patients with atherosclerotic severe carotid stenosis

机译:动脉粥样硬化严重颈动脉狭窄患者脑血管疾病风险因素与钙化斑块特征的相关性

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Objectives: The aim of this study was to evaluate the relationship between the risk factors of cerebral vascular diseases (CVD) and the characteristics of calcified plaques in patients with severe carotid arteriosclerosis stenosis (SCAS). Methods: A total of 402 patients with SCAS who were treated in our hospital between January to December 2016 were included in this study. The patients were divided into calcified plaque group and non-calcified plaque group according to the ultrasonography and computerized tomography angiography (CTA) or digital subtraction angiography (DSA) imaging of SCAS-responsible plaque and the characteristics of calcified plaques evaluated by high-frequency ultrasound. Results: The patients with long-term diabetes mellitus or higher levels of fasting blood glucose were more likely to develop calcified plaques (P = 0.00 and P = 0.021, respectively). In addition, the patients with calcified plaques were mostly smokers (P = 0.016). Their smoking duration and accumulative smoking exposure were higher than those without calcified plaque (P = 0.006 and P = 0.007, respectively). The basal location of calcification (P = 0.004) and the type of patchy calcification (P = 0.00) were both easier to appear in smokers, while non-smokers were more likely to have small granular calcification (P = 0.002). Furthermore, the carotid plaque calcification with mixed-location were more frequently seen in patients with hypertension (P = 0.016). The risk factors independently associated with plaque calcification were significantly associated with smoking status, smoking age, and accumulative smoking exposure, as well as age and diabetes mellitus (all P < 0.05). Conclusion: Smoking, diabetes mellitus and age were independent risk factors for carotid plaque calcification. Smoking and hypertension were associated with specific locations and types of plaque calcification.
机译:目的:本研究的目的是评估脑血管疾病(CVD)危险因素之间的关系以及严重颈动脉硬化狭窄(SCA)患者钙化斑块的特征。方法:2016年1月至12月在2016年12月间在我们院内治疗的402名SCA患者。根据超声检查和计算机断层摄影血管造影(CTA)或数字减法血管造影(DSA)成像分为钙化斑块组和非钙化斑块(DSA)成像的SCAS-Conderised斑块的成像和高频超声评估的钙化斑块的特征。结果:长期糖尿病或更高水平的空腹血糖患者更有可能开发钙化斑块(P = 0.00和P = 0.021)。此外,钙化斑块的患者主要是吸烟者(P = 0.016)。他们的吸烟持续时间和累积吸烟曝光高于没有钙化斑块的吸烟(P = 0.006和P = 0.007)。钙化的基础位置(p = 0.004)和斑块钙化的类型(p = 0.00)都更容易出现在吸烟者中,而非吸烟者更可能具有小的粒状钙化(p = 0.002)。此外,高血压患者更常见的颈动脉斑块钙化更常见(P = 0.016)。与斑块钙化独立相关的风险因素与吸烟状态,吸烟年龄和累积吸烟暴露以及年龄和糖尿病(所有P <0.05)有显着相关。结论:吸烟,糖尿病和年龄是颈动脉斑纹钙化的独立危险因素。吸烟和高血压与特定位置和斑块钙化类型有关。

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