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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >IL‐10 expression in pyramidal neurons after neuropathogenic coronaviral infection
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IL‐10 expression in pyramidal neurons after neuropathogenic coronaviral infection

机译：神经疗法冠状病毒感染后金字塔神经元的IL-10表达

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摘要

The apoptosis of pyramidal neurons in CA2 and CA3 subregions of the hippocampus is induced after infection with Mu‐3 virus (Mu‐3), a neuropathogenic strain of the JHM virus (JHMV), at 4–5?days post‐inoculation (dpi). The viral antigens in the hippocampus are mainly found in the CD11b‐positive cells distributed in the stratum oriens located outside the pyramidal layer, and only a few pyramidal neurons are infected. Furthermore, the apoptotic cells, indicated as showing caspase 3 (Cas3) activation, consist of a high number of uninfected cells. Therefore, it is considered that the apoptotic lesions occur through the indirect effects of infection, and not as a result of direct infection with Mu‐3, similar to the reported neuronal apoptosis in the hippocampus after other types of infection. The apoptosis in the pyramidal neurons is accompanied by various types of proinflammatory cytokines depending on the causative agents. Thus, the local expression of proinflammatory cytokines was studied, revealing no correlation in the distribution of cytokine expression with the subregions showing apoptosis. However, the anti‐inflammatory cytokine IL‐10 was produced by pyramidal neurons of CA2 and CA3 at 3 dpi when there is no destructive change or viral invasion in the hippocampus.
机译：在用MU-3病毒（MU-3）感染后，诱导海马CA2和CA3次区的锥虫神经元的凋亡，JHM病毒（JHMV）的神经脑病菌株，在接种后4-5？天（DPI ）。海马中的病毒抗原主要发现在分布在位于金字塔层外部的地层orens中的CD11b阳性细胞中，并且只感染少数金字塔神经元。此外，表明作为显示Caspase 3（Cas3）活化的凋亡细胞由大量的未感染细胞组成。因此，认为凋亡病变通过感染的间接效应而发生，而不是用MU-3直接感染，类似于在其他类型的感染后报告的海马神经元细胞凋亡。金字塔神经元的凋亡根据致病剂伴随着各种类型的促炎细胞因子。因此，研究了促炎细胞因子的局部表达，揭示了与显示细胞凋亡的次区域的细胞因子表达的分布无关。然而，当海马没有破坏性的变化或病毒侵袭时，通过Ca2和Ca3的金字塔神经元由Ca2和Ca3的锥体神经元产生的抗炎细胞因子IL-10。

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