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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Immunoreactivity of myelin‐associated oligodendrocytic basic protein in Lewy bodies
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Immunoreactivity of myelin‐associated oligodendrocytic basic protein in Lewy bodies

机译：髓鞘相关寡核苷酸碱性蛋白质在lewy体中的免疫反应性

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Myelin‐associated oligodendrocytic basic protein (MOBP) plays a role in structural maintenance of the myelin sheath in the central nervous system. Recent genome analyses have revealed that mutation in MOBP is a risk factor for various neurodegenerative diseases, including Alzheimer's disease (AD), tauopathies and transactivation response DNA‐binding protein 43 kDa proteinopathies. Proteomics analysis has shown that MOBP is a component of cortical Lewy bodies (LBs). However, the immunohistochemical localization of MOBP in the human brain is not known. Using immunohistochemistry, we examined the brain, spinal cord and peripheral ganglia from patients with various neurodegenerative diseases and control subjects. In normal controls, MOBP immunoreactivity was evident in the myelin in the central and peripheral nervous systems (PNS), and neuronal cytoplasm in both the central and PNS. In Parkinson's disease and dementia with LBs, MOBP immunoreactivity was found in the core of LBs in the brainstem, cingulate cortex and sympathetic ganglia. No MOBP immunoreactivity was found in a variety of other neuronal or glial inclusions in other disorders, including multiple system atrophy, AD, Pick's disease, progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Considering that up‐regulation of MOBP has been reported in neurotoxic conditions, accumulation of MOBP in LBs may imply a cytoprotective mechanism in LB disease.
机译：髓鞘相关的少突胶质酶碱性蛋白（MOBP）在中枢神经系统中髓鞘的结构维持中起作用。最近的基因组分析表明，MOBP中的突变是各种神经变性疾病的危险因素，包括阿尔茨海默病（Ad），末疫病和转移反应DNA结合蛋白43 kda蛋白质病。蛋白质组学分析表明，MOBP是皮质石油体（LBS）的成分。然而，未知，MOBP在人脑中的免疫组织化学定位是未知的。使用免疫组织化学，我们研究了各种神经变性疾病和对照受试者的患者的脑，脊髓和外周神经节。在正常对照中，在中央和外周神经系统（PNS）中的髓鞘中，Mobp免疫反应性是明显的，以及中央和PNS的神经元细胞质。在帕金森的疾病和痴呆症，具有LBS的核心免疫反应性在脑干中LBS的核心中发现，Cingulate Cortex和交感神经神经节。在其他疾病的各种其他神经元或胶质夹杂物中没有发现MOBP免疫反应性，包括多种系统萎缩，广告，挑选疾病，进步性激核麻痹，皮质缺卵性变性，艾滋病毒粮食疾病，肌营养的侧面硬化和额颞叶片变性。考虑到在神经毒性条件下报告了MOBP的上调，LBS中MOBP的积累可能意味着LB疾病中的细胞保护机制。

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