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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Pathogenic free‐living amoebic encephalitis in Japan
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Pathogenic free‐living amoebic encephalitis in Japan

机译：致病自由生活的amoebic脑炎在日本

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摘要

Over 600 cases of amoebic encephalitis caused by pathogenic free‐living amoebas ( Balamuthia mandrillaris , Acanthamoeba spp., and Naegleria fowleri ) have been reported worldwide, and in Japan, 24 cases have been reported from the first case in 1976 up to 2018. Among these cases, 18 were caused by B. mandrillaris , four by Acanthamoeba spp., one by N. fowleri , and one was of unknown etiology. Additionally, eight cases were diagnosed with encephalitis due to pathogenic free‐living amoebas before death, but only three cases were successfully treated. Unfortunately, all other cases were diagnosed by autopsy. These facts indicate that an adequate diagnosis is difficult, because encephalitis due to pathogenic free‐living amoebas does not show typical symptoms or laboratory findings. Moreover, because the number of cases is limited, other cases might have been missed outside of those diagnosed by autopsy. Cases of encephalitis caused by B. mandrillaris have been reported from all over Japan, with B. mandrillaris recently isolated from soil in Aomori prefecture. Therefore, encephalitis caused by pathogenic free‐living amoebas should be added to the differential diagnosis of encephalitis patients.
机译：在全世界均报告了致病自由生活Amoebas（Balamuthia Mandrillaris，Acanthamoeba SPP。和Naeglyia Fowleri）引起的600例患者脑炎患者（Balamuthia Mandrillaris），并在日本，1976年的第一次案件报告了24个案件。其中这些病例，18是由B.Mandrillaris引起的，四个由Acanthamoeba SPP引起的。，一个由N. Fowleri，一个是未知的病因。此外，由于死亡前的病原自由生活作物组，诊断出8例患者患有脑炎，但仅成功处理了三种情况。不幸的是，所有其他病例都被尸检诊断出来。这些事实表明，足够的诊断是困难的，因为由于致病性自由生活的脑炎未显示出典型的症状或实验室发现。此外，由于案件的数量有限，因此可能错过了尸检诊断的人之外的其他病例。据报道，B.Mandrillaris引起的脑炎病例已从日本各地报告，B.Mandrillaris最近从海莫利州的土壤中分离出来。因此，应加入由病原自由生活作物组织引起的脑炎患者患脑炎患者的鉴别诊断。

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