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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere
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An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere

机译：一种老年人的恶性小型细胞胶质瘤，出血与钙化的pilbellar半球中的钙化皮霉菌星形细胞瘤成分共存

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摘要

Pilocytic astrocytoma is a less aggressive form of glial tumor that commonly occurs in the pediatric population, and its malignant transformation is extremely rare. Here, we report an elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component. An 80‐year‐old male was found to have a right cerebellar non‐enhanced tumor with hematoma adjoining a calcified nodule. The lesion was surgically removed, and a histological examination verified that the tumor was a malignant small cell glioma with hemorrhagic change and the calcified nodule showed features of pilocytic astrocytoma. Genetic analyses revealed no glioma‐relevant genetic alterations such as IDH and BRAF mutations. Although calcification is generally observed in slowly growing gliomas, the aggressive clinical course of calcified cerebellar pilocytic astrocytoma has been previously reported. Our extremely rare case shows that careful follow‐up is necessary even for calcified pilocytic astrocytomas.
机译：紫叶蛋白星形细胞瘤是一种不太侵略性的胶质肿瘤形式，通常发生在儿科人群中，并且其恶性转化极为罕见。在这里，我们向钙化硫纤维星形细胞瘤成分共存了一位老年人恶性小细胞胶质瘤的老年病例。发现一个80岁的男性被发现具有右侧小脑非增强肿瘤，血肿邻近钙化结节。外科病变被手术去除，并且组织学检查核实肿瘤是一种具有出血变化的恶性小细胞胶质瘤，钙化结节表现出硫胺星形细胞瘤的特征。遗传分析显示没有胶质瘤相关的遗传改变，如IDH和BRAF突变。尽管在缓慢生长的胶质瘤中通常观察到钙化，但是先前已经报道了钙化小脑霉菌星形细胞瘤的侵袭性临床进程。我们非常罕见的案例表明，即使对于钙化的plocytic星形细胞瘤，甚至是必要的仔细随访。

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