• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Autopsied centenarian case of Alzheimer's disease combined with hippocampal sclerosis, TDP-43, and -synuclein pathologies
【24h】

Autopsied centenarian case of Alzheimer's disease combined with hippocampal sclerosis, TDP-43, and -synuclein pathologies

机译：Alzheimer疾病的尸检百年人案例结合海马硬化，TDP-43和-synuclein病变

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A Japanese woman showed slowly progressive memory disturbance starting at the age of 84 years, and disorientation gradually appeared. Head computed tomography revealed severe hippocampal atrophy, whereas the atrophy of the frontal lobe was considerably mild for her age. Behavioral and psychological symptoms of dementia were relatively inconspicuous during the disease course. Apolipoprotein E gene analysis showed epsilon 3/epsilon 4 heterozygosity. She died at the age of 100 years and she was clinically diagnosed as having Alzheimer's disease (AD). Autopsy revealed numerous neurofibrillary tangles, particularly in the hippocampal region, and extensively distributed senile plaques in the brain. Although the findings were compatible with the pathological criteria for AD, combined pathologies of hippocampal sclerosis, trans-activation response DNA-binding protein 43 kDa, and -synuclein were also revealed. We believe that the clinicopathological findings of the present case are of significance for the diagnosis of elderly dementia and pathogenesis of AD.
机译：一名日本女子在84岁时开始逐渐进步，令人震惊地逐渐出现。头层计算机断层扫描显示严重的海马萎缩，而额叶的萎缩对于她的年龄相当轻微。在疾病过程中，痴呆的行为和心理症状相对不起眼​​。载脂蛋白E基因分析显示Epsilon 3 / epsilon 4杂合子。她在100岁时死亡，她在临床上被诊断为具有阿尔茨海默病（广告）。尸检揭示了许多神经纤维绦虫缠结，特别是在海马区域，并且在大脑中广泛分布了老年斑块。虽然该发现与AD的病理标准相容，但也揭示了海马硬化，转发响应DNA结合蛋白43kDA和-Synucin的组合病理。我们认为，本案例的临床病理发现对于诊断老年痴呆和AD发病机制具有重要意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号