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首页> 外文期刊>Neurochemical research >Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors
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Voluntary Exercise During Adolescence Mitigated Negative the Effects of Maternal Separation Stress on the Depressive-Like Behaviors of Adult Male Rats: Role of NMDA Receptors

机译：青春期期间自愿运动缓解了母体分离应激对成年雄性大鼠抑郁样行为的影响：NMDA受体的作用

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Evidence indicates that experiencing early-life stress (ELS) is a risk factor for the development of mental disorders such as depression. Maternal separation stress (MS) is a valid animal model of ELS that caused to induce long-lasting effects on the brain and behaviors of animals. It hypothesized that adolescence is a critical stage in which the brain is still developing, and applying (non)pharmacological therapies in this period may attenuate the effects of ELS on the brain and behavior. Male rats were subjected to MS from postnatal day (PND) 2-14, and the stressed animals were then treated with (1) chronic fluoxetine (FLX) (5 mg/kg) and (2) voluntary running wheel exercise (RW) from PND 30, for 30 days. Then, we subjected the animals to behavioral and molecular assessments at PND 60. Our data showed that MS provoked depressive-like behaviors in rats, tested by the forced swimming test, splash test, and sucrose preference test. Additionally, we found that MS increased the gene expression of the NR2A (and not NR2B) subunit of N-methyl-d-aspartate (NMDA) receptors in the hippocampus of adult rats. Both FLX and RW treatments during adolescence were able to mitigate the negative effects of ELS on stressed animals. These results highlighted the importance of adolescence in treating stressed animals with FLX/voluntary RW exercise to alleviate the depressive effects of ELS. In addition, we found that ELS altered the transcriptional level of Grin2a (and not Grin2b) in the hippocampus. Finally, our results showed that FLX/voluntary RW exercise during adolescence could normalize altered expression of Grin2a in the hippocampus of adult rats.
机译：证据表明，经历早期压力（ELS）是抑郁症等精神障碍发展的危险因素。母体分离应力（MS）是ELS的有效动物模型，导致对动物的大脑和行为引起持久的影响。它假设青春期是大脑仍在开发的关键阶段，并且在此期间施用（非）药理治疗可能会抑制ELS对大脑和行为的影响。从出生后的日期（PND）2-14中对MS进行雄性大鼠，然后用（1）慢性氟西汀（FLX）（5mg / kg）和（2）自愿运行轮运动（RW）处理压力的动物。 PND 30，30天。然后，我们将这些动物与PND 60进行行为和分子评估。我们的数据显示，由强制游泳试验，飞溅试验和蔗糖偏好测试测试的大鼠中的MS激发抑郁样行为。另外，我们发现MS增加了成年大鼠海马中N-甲基-D-天冬氨酸（NMDA）受体的NR2A（而不是NR2B）亚基的基因表达。在青春期期间的FLX和RW治疗能够减轻ELS对应激动物的负面影响。这些结果强调了青春期在用FLX /自愿RW练习治疗强调动物时的重要性，以减轻ELS的抑郁作用。此外，我们发现ELS在海马中改变了GRIN2A（而不是GRIN2B）的转录水平。最后，我们的结果表明，青春期的FLX /自愿RW锻炼可能是在成年大鼠海马中的改变改变的Grin2a表达。

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