Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondria; Fission during Induction

Divakaruni Sai Sachin; Van Dyke Adam M.; Chandra Ramesh; LeGates Tara A.; Contreras Minerva; Dharmasri Poorna A.; Higgs Henry N.; Lobo Mary Kay; Thompson Scott M.; Blanpied Thomas A.

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Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondria; Fission during Induction

机译：长期电位需要快速爆裂树突线粒体; 归纳期间裂变

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Synaptic transmission is bioenergetically demanding, and the diverse processes underlying synaptic plasticity elevate these demands. Therefore, mitochondrial functions, including ATP synthesis and Ca2+ handling, are likely essential for plasticity. Although axonal mitochondria have been extensively analyzed, LTP is predominantly induced postsynaptically, where mitochondria are understudied. Additionally, though mitochondrial fission is essential for their function, signaling pathways that regulate fission in neurons remain poorly understood. We found that NMDAR-dependent LTP induction prompted a rapid burst of dendritic mitochondrial fission and elevations of mitochondrial matrix Ca2+. The fission burst was triggered by cytosolic Ca2+ elevation and required CaMKII, actin, and Drp1, as well as dynamin 2. Preventing fission impaired mitochondrial matrix Ca2+ elevations, structural LTP in cultured neurons, and electrophysiological LTP in hippocampal slices. These data illustrate a novel pathway whereby synaptic activity controls mitochondrial fission and show that dynamic control of fission regulates plasticity induction, perhaps by modulating mitochondrial Ca2+ handling.

机译：突触传递是生物能级要求，突触塑性的不同过程提高了这些需求。因此，包括ATP合成和CA2 +处理的线粒体功能可能对可塑性至关重要。虽然已经广泛分析了轴突线粒体，但LTP主要突出地诱导，其中受到线粒体的影响。此外，虽然线粒体裂变对于它们的功能至关重要，但调节神经元裂变的信号通路仍然明确地理解。我们发现NMDAR依赖性LTP诱导促使线粒体线粒体裂变的快速爆发和线粒体基质CA2 +的升高。裂变爆发由细胞溶质Ca2 +升降和所需的Camkii，Actin和DRP1触发，以及Dynamin 2。预防裂变受损的线粒体基质Ca2 +升高，结构LTP在培养的神经元中，以及海马切片中的电生理LTP。这些数据说明了一种新的途径，由此突触活动控制线粒体裂变并表明裂变的动态控制调节塑性诱导，也许通过调节线粒体CA2 +处理。

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《Neuron》 |2018年第4期|共23页
作者
Divakaruni Sai Sachin; Van Dyke Adam M.; Chandra Ramesh; LeGates Tara A.; Contreras Minerva; Dharmasri Poorna A.; Higgs Henry N.; Lobo Mary Kay; Thompson Scott M.; Blanpied Thomas A.;
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作者单位

Univ Maryland Sch Med Med Scientist Training Program Baltimore MD 21201 USA;

Univ Maryland Sch Med Dept Physiol Baltimore MD 21201 USA;

Univ Maryland Sch Med Dept Anat &

Neurobiol Baltimore MD 21201 USA;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Univ Maryland Sch Med Dept Physiol Baltimore MD 21201 USA;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Dartmouth Coll Geisel Sch Med Dept Biochem Hanover NH 03755 USA;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

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正文语种 eng
中图分类神经病学;
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1. Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondria; Fission during Induction [J] . Divakaruni Sai Sachin, Van Dyke Adam M., Chandra Ramesh, Neuron . 2018,第4期

机译：长期电位需要快速爆裂树突线粒体; 归纳期间裂变
2. Rapid report: postsynaptic bursting is essential for 'Hebbian' induction of associative long-term potentiation at excitatory synapses in rat hippocampus. [J] . Pike FG, Meredith RM, Olding AW, The Journal of Physiology . 1999,第Pta2期

机译：快速报告：突触后爆发对于大鼠海马在兴奋性突触中“ Hebbian”诱导长期联合增强作用至关重要。
3. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. [J] . Tsokas P, Grace EA, Chan P, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2005,第24期

机译：诱导后期长期增强后，局部蛋白质合成介导了树突状伸长因子1A的快速增加。
4. Computational study of the role of calcium in late long-term potentiation induction on the basis of tripartite synapse structure [C] . Dehkordy Soheila Roohi, Bahrami F., Janahmadi Mahyar Iranian Conference on Electrical Engineering . 2014

机译：三方突触结构基础上钙在晚期长期增强诱导中的作用的计算研究
5. Dendritic spine expansion induced by hippocampal long-term potentiation. [D] . Lang, Cynthia. 2008

机译：海马长期增强诱导树突状脊柱扩张。
6. Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term Potentiation [O] . Panayiotis Tsokas, Elizabeth A. Grace, PokMan Chan, 2005

机译：诱导后期长期增强后本地蛋白质合成介导树突状伸长因子1A的迅速增加。
7. Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction [O] . Sai Sachin Divakaruni, Adam M. Van Dyke, Ramesh Chandra, 2018

机译：长期潜力需要在诱导过程中快速爆发树突线粒体裂变

Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondria; Fission during Induction

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