Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies

Davies Caitlin; Spires-Jones Tara L.

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Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies

机译：补充Tau：新数据表明，补体系统涉及到末端的变性

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Innate immunity is increasingly recognized to contribute to the pathogenesis of neurodegenerative disorders. In this issue of Neuron, Dejanovic et al. (2018) and Litvinchuk et al. (2018) describe mechanisms by which the complement system influences tau-mediated degeneration in mouse models of tauopathy.

机译：先天免疫越来越认识到有助于神经变性障碍的发病机制。在这个神经元的问题中，Dejanovic等。（2018）和Litvinchuk等人。（2018）描述了补体系统影响TauOpathy小鼠模型中Tau介导的退化的机制。

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《Neuron》 |2018年第6期|共3页
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Davies Caitlin; Spires-Jones Tara L.;
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Univ Edinburgh UK Dementia Res Inst 1 George Sq Edinburgh EH8 9JZ Midlothian Scotland;

Univ Edinburgh UK Dementia Res Inst 1 George Sq Edinburgh EH8 9JZ Midlothian Scotland;

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正文语种 eng
中图分类神经病学;
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1. Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies [J] . Davies Caitlin, Spires-Jones Tara L. Neuron . 2018,第6期

机译：补充Tau：新数据表明，补体系统涉及到末端的变性
2. Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. [J] . de Silva R, Lashley T, Gibb G, Neuropathology and applied neurobiology . 2003,第3期

机译：tauopathies中的病理性包涵体包含不同的tau补体，具有三个或四个微管结合重复域，如新的特异性单克隆抗体所示。
3. The analyzation of complement deposition in tauopathies [J] . Akatsu Hiroyasu, Ogawa Norihiro, Kanesaka Takeshi, Immunobiology: Zeitschrift fur Immunitatsforschung . 2016,第10期

机译：眼睑病中补体沉积的分析
4. Efficient Provision of KPIs with High Information Content as a Complement to Conventional Data Management Systems (DCS, PI) Operating Experience with Expert Systems [C] . Dennis Braun, Urs Steinmetz POWER-GEN Europe Renewable Energy World Europe . 2017

机译：高效提供具有高信息内容的KPI作为与专家系统的传统数据管理系统（DCS，PI）操作经验的补充
5. Iron-induced complement dysregulation in the retinal pigment epithelium: implications for age-related macular degeneration [D] . Li, Yafeng 2015

机译：铁诱导的视网膜色素上皮的补体失调：与年龄相关的黄斑变性的影响
6. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice [O] . Markus Britschgi, Yoshiko Takeda-Uchimura, Edward Rockenstein, 2012

机译：末端补体途径抑制剂的缺乏促进小鼠神经元tau病理和变性
7. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease [O] . Alexandra Litvinchuk, Ying-Wooi Wan, Dan B. Swartzlander, 2018

机译：补体C3AR灭活衰减TAU病理学，并逆转在介体模型和阿尔茨海默病中造成的免疫网络
8. Effect of Agents That Produce Membrane Disorder on Lysis of Erythrocytes by Complement (Complement Channels/Membrane Channels/Complement Cytotoxicity) [R] . Shin, M. L., Hansch, G., Mayer, M. M. 1981

机译：产生膜紊乱的药物通过补体（补体通道/膜通道/补体细胞毒性）对红细胞裂解的影响

Complementing Tau: New Data Show that the Complement System Is Involved in Degeneration in Tauopathies

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