Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

Oranth Alexandra; Schultheis Christian; Tolstenkov Oleg; Erbguth Karen; Nagpal Jatin; Hain David; Brauner Martin; Wabnig Sebastian; Costa Wagner Steuer; McWhirter Rebecca D.; Zels Sven; Palumbos Sierra; Miller David M. III; Beets Isabel; Gottschalk Alexander

首页> 外文期刊>Neuron >Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

【24h】

Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

机译：食物感应通过多巴胺和神经肽信号在分布式神经网络中调制运动

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Finding food and remaining at a food source are crucial survival strategies. We show how neural circuits and signaling molecules regulate these food-related behaviors in Caenorhabditis elegans. In the absence of food, AVK interneurons release FLP-1 neuropeptides that inhibit motorneurons to regulate body posture and velocity, thereby promoting dispersal. Conversely, AVK photoinhibition promoted dwelling behavior. We identified FLP-1 receptors required for these effects in distinct motoneurons. The DVA interneuron antagonizes signaling from AVK by releasing cholecystokinin-like neuropeptides that potentiate cholinergic neurons, in response to dopaminergic neurons that sense food. Dopamine also acts directly on AVK via an inhibitory dopamine receptor. Both AVK and DVA couple to head motoneurons by electrical and chemical synapses to orchestrate either dispersal or dwelling behavior, thus integrating environmental and proprioceptive signals. Dopaminergic regulation of food-related behavior, via similar neuropeptides, may be conserved in mammals.

机译：寻找食物并剩下的食物来源是至关重要的生存策略。我们展示了神经电路和信号分子如何调节Caenorhabditis elegans中这些与食物相关的行为。在没有食物的情况下，AVK Interneurons释放FLP-1神经肽，抑制Motorneurons来调节身体姿势和速度，从而促进分散。相反，AVK PhotoInchitch促进了住宅行为。我们鉴定了在不同的运动神经元中这些效果所需的FLP-1受体。 DVA Interneuron通过释放胆碱能神经元的胆囊蛋白样神经元来拮抗AVK的信号传导，响应于感知食物的多巴胺能神经元。多巴胺还通过抑制多巴胺受体直接作用于AVK。 AVK和DVA夫妇通过电气和化学突触通过电气和化学突触耦合，以协调分散或居住行为，从而整合环境和预防信号。通过类似神经肽的食物相关行为的多巴胺能调节可能在哺乳动物中保存。

著录项

来源
《Neuron》 |2018年第6期|共25页
作者
Oranth Alexandra; Schultheis Christian; Tolstenkov Oleg; Erbguth Karen; Nagpal Jatin; Hain David; Brauner Martin; Wabnig Sebastian; Costa Wagner Steuer; McWhirter Rebecca D.; Zels Sven; Palumbos Sierra; Miller David M. III; Beets Isabel; Gottschalk Alexander;
展开▼
作者单位

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Boehringer Ingelheim Pharma GmbH &

Co KG Birkendorfer Str 65 D-88400 Biberach Germany;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Johannes Gutenberg Univ Mainz Univ Med Ctr German Resilience Ctr Duesbergweg 6 D-55128 Mainz;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

Vanderbilt Univ Dept Cell &

Dev Biol Nashville TN 37240 USA;

Univ Leuven Dept Biol Naamsestr 59 B-3000 Leuven Belgium;

Vanderbilt Univ Dept Cell &

Dev Biol Nashville TN 37240 USA;

Vanderbilt Univ Dept Cell &

Dev Biol Nashville TN 37240 USA;

Univ Leuven Dept Biol Naamsestr 59 B-3000 Leuven Belgium;

Goethe Univ Buchmann Inst Mol Life Sci Max von Laue Str 15 D-60438 Frankfurt Germany;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词

相似文献

外文文献
中文文献
专利

1. Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network [J] . Oranth Alexandra, Schultheis Christian, Tolstenkov Oleg, Neuron . 2018,第6期

机译：食物感应通过多巴胺和神经肽信号在分布式神经网络中调制运动
2. 5-HT and dopamine modulates CaV1.3 calcium channels involved in postinhibitory rebound in the spinal network for locomotion in lamprey. [J] . Wang D, Grillner S, Wallen P Journal of Neurophysiology . 2011,第3期

机译：5-HT和多巴胺调节CaV1.3钙通道，该通道参与抑制在鳗鱼中运动的脊髓网络中的抑制后反弹。
3. Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks [J] . Shafiei Golia, Zeighami Yashar, Clark Crystal A., Cerebral cortex . 2019,第1期

机译：多巴胺信号传导调制内在脑网络的稳定性和集成
4. Elucidating the Design Principles of Signal Transduction Networks - application to Dopamine and Calcium signaling in reinforcement learning [C] . Shuoqi Zhang, Elling W. Jacobsen IFAC World Congress . 2011

机译：阐明信号转导网络的设计原理 - 在加固学习中的多巴胺和钙信号的应用
5. Dynamic regulation of R7BP (R7 Binding Protein) containing R7 RGS (R7 Regulators of G protein Signaling) protein complexes: Role in controlling neuronal dopamine and opioid signaling in the striatum. [D] . Anderson, Garret R. 2010

机译：包含R7 RGS（G蛋白信号的R7调节剂）蛋白复合物的R7BP（R7结合蛋白）的动态调节：在纹状体中控制神经元多巴胺和阿片样物质信号中的作用。
6. Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks [O] . Golia Shafiei, Yashar Zeighami, Crystal A Clark, -1

机译：多巴胺信号调节内在大脑网络的稳定性和整合性。
7. Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks [O] . Golia Shafiei, Yashar Zeighami, Crystal A Clark, 2018

机译：多巴胺信号传导调制内在脑网络的稳定性和集成

Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

摘要

著录项

相似文献

相关主题

期刊订阅