Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons

Cristina Mazuski; John H. Abel; Samantha P. Chen; Tracey O. Hermanstyne; Jeff R. Jones; Tatiana Simon; Francis J. Doyle; Erik D. Herzog

首页> 外文期刊>Neuron >Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons

【24h】

Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons

机译：昼夜节律的夹带取决于探测SCN神经元的射击率和神经肽释放

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker, integrating environmental input to align physiological and behavioral rhythms to local time cues. Approximately 10% of SCN neurons express vasoactive intestinal polypeptide (VIP); however, it is unknown how firing activity of VIP neurons releases VIP to entrain circadian rhythms. To identify physiologically relevant firing patterns, we optically tagged VIP neurons and characterized spontaneous firing over 3?days. VIP neurons had circadian rhythms in firing rate and exhibited two classes of instantaneous firing activity. We next tested whether physiologically relevant firing affected circadian rhythms through VIP release. We found that VIP neuron stimulation with high, but not low, frequencies shifted gene expression rhythmsin?vitrothrough VIP signaling.In?vivo, high-frequency VIP neuron activation rapidly entrained circadian locomotor rhythms. Thus, increases in VIP neuronal firing frequency release VIP and entrain molecular and behavioral circadian rhythms. Video AbstractDisplay Omitted.

机译：哺乳动物的哺乳动物的核心核（SCN）用作主昼夜昼夜昼夜节目起搏器，整合环境输入以将生理和行为节律与当地时间提示一致。大约10％的SCN神经元表达血管活性肠道多肽（VIP）;然而，尚不清楚VIP神经元的射击活动如何发布VIP以纳入昼夜节律。为了鉴定生理相关的烧制模式，我们光学标记了VIP神经元并以3个天的自发射击。 VIP神经元在射击率上有昼夜节律，并展示了两类瞬间射击活动。我们接下来通过VIP释放测试了是否会对生理相关的射击影响昼夜节律影响。我们发现VIP神经元刺激高，但不低，频率偏移基因表达节奏？VITROCHROUCH VIP信号。在高频VIP神经元激活快速夹带昼夜活动节奏。因此，VIP神经元烧制频率释放VIP的增加和夹带分子和行为昼夜节律。 Video AbstractDisplay省略。

著录项

来源
《Neuron》 |2018年第3期|共9页
作者
Cristina Mazuski; John H. Abel; Samantha P. Chen; Tracey O. Hermanstyne; Jeff R. Jones; Tatiana Simon; Francis J. Doyle; Erik D. Herzog;
展开▼
作者单位

Department of Biology Washington University in St. Louis;

Department of Systems Biology Harvard Medical School;

Department of Biology Washington University in St. Louis;

Department of Biology Washington University in St. Louis;

Department of Biology Washington University in St. Louis;

Department of Biology Washington University in St. Louis;

Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University;

Department of Biology Washington University in St. Louis;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
vasoactive intestinal peptide; suprachiasmatic nucleus; neuropeptide; Period gene; multielectrode array; optogenetic; channelrhodopsin; daily oscillation;

机译：血管活性肠肽;术治疗核;神经肽;期基因;多电极阵列;致光学;海峡流动公司;日常振荡;

相似文献

外文文献
专利

1. Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons [J] . Cristina Mazuski, John H. Abel, Samantha P. Chen, Neuron . 2018,第3期

机译：昼夜节律的夹带取决于探测SCN神经元的射击率和神经肽释放
2. Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior [J] . Jones Jeff R., Tackenberg Michael C., McMahon Douglas G. Nature neuroscience . 2015,第3期

机译：操纵昼夜节律神经元放电速率可重置分子昼夜节律和行为
3. Circadian firing-rate rhythms and light responses of rat habenular nucleus neurons in vivo and in vitro. [J] . Zhao H, Rusak B Neuroscience: An International Journal under the Editorial Direction of IBRO . 2005,第2期

机译：人体和体外大鼠fir状核神经元的昼夜节律节律和光反应。
4. Circadian rhythm pacemaker neuropeptides "PDF" in nocturnal insect cricket gryllus bimaculatus:cDNA cloning,mRNA expression,and nuclear localization [C] . Yoshiro Chuman, Ayami Matsushima, Yasuyuki Shimohigashi, the International Peptide Symposium . 2001

机译：昼夜节律起搏器神经缺乏“PDF”在夜间昆虫蟋蟀Glyllus Bimaculatus：cDNA克隆，mRNA表达和核局部化
5. The Role of VIP SCN Neurons in Circadian Physiology and Behavior [D] . Mazuski, Cristina. 2017

机译：VIP SCN神经元在昼夜学会生理学和行为中的作用
6. Entrainment of circadian rhythms depends on firing rates and neuropeptide release of VIP SCN neurons [O] . Cristina Mazuski, John H. Abel, Samantha P. Chen, -1

机译：昼夜节律的引诱取决于VIP SCN神经元的放电速度和神经肽释放
7. Adult mice lacking VIP SCN neurons retain circadian locomotor behavior but exhibit dampened daily glucocorticoid rhythms [O] . Cristina Mazuski, Samantha P. Chen, Erik D. Herzog 2020

机译：缺乏VIP SCN神经元的成人小鼠保留昼夜运动行为，但表现出湿度的每日糖皮质激素节奏
8. Study of SCN Neurochemistry using in Vivo Microdialysis in the Conscious Brain:Correlation with Circadian Activity Rhythms [R] . Glass, J. D. 1996

机译：sCN神经化学在有意识的大脑中的体内微透析研究：与昼夜节律活动节律的相关性

Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons

摘要

著录项

相似文献

相关主题

期刊订阅