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Segregated Subnetworks of Intracortical Projection Neurons in Primary Visual Cortex

机译：在原发性视觉皮层中分离的地管内投影神经元的子网

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The rules by which neurons in neocortex choose their synaptic partners are not fully understood. In sensory cortex, intermingled neurons encode different attributes of sensory inputs and relay them to different long-range targets. While neurons with similar responses to sensory stimuli make connections preferentially, the relationship between synaptic connectivity within an area and long-range projection target remains unclear. We examined the local connectivity and visual responses of primary visual cortex neurons projecting to anterolateral (AL) and posteromedial (PM) higher visual areas in mice. Although the response properties of layer 2/3 neurons projecting to different targets were often similar, they avoided making connections with each other. Thus, projection target, in addition to response similarity, constrains local synaptic connectivity of AL and PM projection neurons. We propose that reduced crosstalk between different populations of projection neurons permits independent function of these output channels.
机译：Neocortex中神经元选择突触伙伴的规则不完全理解。在感官皮质中，混合的神经元编码感觉输入的不同属性并将其继电到不同的远程目标。虽然具有与感觉刺激相似响应的神经元优先进行连接，但是区域内的突触连接率和远程投影目标之间的关系仍不清楚。我们检查了突出的原发性视觉皮质神经元的局部连通性和视觉响应，突出到小鼠的前视网膜（Al）和后退（PM）更高的视觉区域。虽然突出到不同目标的第2/3层神经元的响应性质通常是相似的，但它们避免彼此连接。因此，除了响应相似性之外，投影目标限制了Al和PM投影神经元的局部突触连接。我们提出在不同群体的投影神经元之间的减少串扰允许这些输出通道的独立功能。

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