...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Sensorimotor Integration and Amplification of Reflexive Whisking by Well-Timed Spiking in the Cerebellar Corticonuclear Circuit
【24h】

Sensorimotor Integration and Amplification of Reflexive Whisking by Well-Timed Spiking in the Cerebellar Corticonuclear Circuit

机译：通过在小脑皮质核电路中通过定时尖刺搅拌反射搅拌的传感器集成和放大

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To test how cerebellar crus I/II Purkinje cells and their targets in the lateral cerebellar nuclei (CbN) integrate sensory and motor-related inputs and contribute to reflexive movements, we recorded extracellularly in awake, head-fixed mice during non-contact whisking. Ipsilateral or contralateral air puffs elicited changes in population Purkinje simple spike rates that matched whisking kinematics (～1?Hz/1° protraction). Responses remained relatively unaffected when ipsilateral sensory feedback was removed by lidocaine but were reduced by optogenetically inhibiting the reticular nuclei. Optogenetically silencing cerebellar output suppressed movements. During puff-evoked whisks, both Purkinje and CbN cells generated well-timed spikes in sequential 2- to 4-ms windows at response onset, such that they alternately elevated their firing rates just before protraction. With spontaneous whisks, which were smaller than puff-evoked whisks, well-timed spikes were absent and CbN cells were inhibited. Thus, sensory input can facilitate millisecond-scale, well-timed spiking in Purkinje and CbN cells and amplify reflexive whisker movements.
机译：为了测试Cerebellar Crus I / II purkinje细胞及其在横向小脑核（CBN）中的靶点，整合了感觉和与电动机相关的输入并有助于反射运动，我们在唤醒期间令人醒着，头固定小鼠在唤醒中记录。同侧或对侧空气吹气引发了Purkinje简单尖峰率的突出的变化，搭配搅拌运动学（〜1？Hz / 1°突出）。当通过Lidocaine除去同侧感觉反馈时，应对剩余的反应相对不受影响，而是通过致光学抑制网状核来减少。光学沉默的小脑输出抑制了运动。在Puff-Excoked智焰期间，Pulkinje和CBN细胞在响应发作时在顺序2至4-ms窗口中产生了井定时尖峰，使得它们在突起之前交替地升高了它们的烧制率。具有比浮夸令人震惊的耳语小的自发耳语，不存在良好定时的尖峰，并且抑制了CBN细胞。因此，感官输入可以促进毫秒级，在Purikinje和CBN细胞中定时尖刺，并扩增反射晶须运动。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号