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首页> 外文期刊>Neuron >The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference
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The Hippocampus and Neocortical Inhibitory Engrams Protect against Memory Interference

机译：海马和新皮质抑制性倾向于防止记忆干扰

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摘要

Our experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that protect memories from interference. The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations of context-dependent memories are pattern separated according to their relational overlap. The second mechanism involves neocortical inhibition. When we reduce the concentration of neocortical GABA using trans-cranial direct current stimulation (tDCS), neocortical memory interference increases in proportion to the reduction in GABA, which in turn predicts behavioral performance. These findings suggest that memory interference is mediated by both the hippocampus and neocortex, where the hippocampus separates overlapping but context-dependent memories using relational information, and neocortical inhibition prevents unwanted co-activation between overlapping memories.
机译：我们的经历往往彼此重叠，但我们能够选择性地回忆起个人记忆来指导决策和未来的行动。支持这种精确记忆召回的神经机构仍然不清楚。这里，使用超高场7T MRI，我们揭示了两个保护存储器免于干扰的不同机制。第一机制涉及海马，其中血氧级依赖性（粗体）信号预测存储器干扰的行为测量，并且根据其关系重叠分离了上下文依赖记忆的表示。第二种机制涉及新皮质抑制。当我们使用反式颅直流刺激（TDC）降低Neocortical GABA的浓度时，Neocortical存储器干扰与GABA的减少成比例地增加，这反过来预测行为性能。这些发现表明，存储器干扰由海马和Neocortex介导，其中海马分离使用关系信息的重叠但上下文相关的存储器，并且新奇抑制可以防止重叠存储器之间的不希望的共激活。

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  • 来源
    《Neuron》 |2019年第3期|共20页
  • 作者

    Koolschijn Renee S.; Emir Uzay E.; Pantelides Alexandros C.; Nili Hamed; Behrens Timothy E. J.; Barron Helen C.;

  • 作者单位

    Univ Oxford FMRIB John Radcliffe Hosp Wellcome Ctr Integrat Neuroimaging Oxford OX3 9DU England;

    Univ Oxford FMRIB John Radcliffe Hosp Wellcome Ctr Integrat Neuroimaging Oxford OX3 9DU England;

    Univ Oxford FMRIB John Radcliffe Hosp Wellcome Ctr Integrat Neuroimaging Oxford OX3 9DU England;

    Univ Oxford Dept Expt Psychol 15 Pk Rd Oxford OX1 3AQ England;

    Univ Oxford FMRIB John Radcliffe Hosp Wellcome Ctr Integrat Neuroimaging Oxford OX3 9DU England;

    Univ Oxford FMRIB John Radcliffe Hosp Wellcome Ctr Integrat Neuroimaging Oxford OX3 9DU England;

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  • 正文语种 eng
  • 中图分类 神经病学;
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