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Rapid Plasticity of Higher-Order Thalamocortical Inputs during Sensory Learning

机译：感官学习期间，高阶丘脑引入的快速可塑性

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摘要

Neocortical circuits are sensitive to experience, showing both anatomical and electrophysiological changes in response to altered sensory input. We examined input- and cell-type-specific changes in thalamo- and intracortical pathways during learning using an automated, home-cage sensory association training (SAT) paradigmcoupling multi-whisker stimulation to a water reward. We found that the posterior medial nucleus (POm) but not the ventral posterior medial (VPM) nucleus of the thalamus drives increased cortical activity after 24 h of SAT, when behavioral evidence of learning first emerges. Synaptic strengthening within the POm thalamocortical pathway was first observed at thalamic inputs to L5 and was not generated by sensory stimulation alone. Synaptic changes in L2 were delayed relative to L5, requiring 48 h of SAT to drive synaptic plasticity at thalamic and intracortical inputs onto L2 Pyr neurons. These data identify the POm thalamocortical circuit as a site of rapid synaptic plasticity during learning and suggest a temporal sequence to learning-evoked synaptic changes in the sensory cortex.
机译：Neocortical电路对体验敏感，响应于改变的感觉输入，显示了解剖学和电生理学变化。在使用自动的家庭笼子感官协会培训（SAT）范式刺激到水奖励，我们在学习期间检查了在学习期间的泰拉莫和内部途径的特异性变化。我们发现，当学习的行为证据首次出现时，后，丘脑后内侧核（POM）但不是腹部后内侧（POM）但不是腹部后内侧（VPM）核（VPM）核。首先在丘脑输入到L5的POM ThalamoCortical途径内的突触强化，并不仅由感觉刺激产生的。 L2的突触变化相对于L5延迟，需要48小时，以驱动丘脑的突触可塑性在L2 Pyronon上。这些数据将POM ThalamoCortical电路识别为学习期间快速突触塑性的部位，并表明了感觉皮质中的学习诱发突触变化的时间序列。

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  • 来源
    《Neuron》 |2019年第2期|共19页
  • 作者

    Audette Nicholas J.; Bernhard Sarah M.; Ray Ajit; Stewart Luke T.; Barth Alison L.;

  • 作者单位

    Carnegie Mellon Univ Dept Biol Sci 4400 5th Ave Pittsburgh PA 15213 USA;

    Carnegie Mellon Univ Dept Biol Sci 4400 5th Ave Pittsburgh PA 15213 USA;

    Carnegie Mellon Univ Dept Biol Sci 4400 5th Ave Pittsburgh PA 15213 USA;

    Carnegie Mellon Univ Dept Biol Sci 4400 5th Ave Pittsburgh PA 15213 USA;

    Carnegie Mellon Univ Dept Biol Sci 4400 5th Ave Pittsburgh PA 15213 USA;

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  • 正文语种 eng
  • 中图分类 神经病学;
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