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Inference-Based Decisions in a Hidden State Foraging Task: Differential Contributions of Prefrontal Cortical Areas

机译:隐藏状态觅食任务中的基于推断的决策:前额外皮质区域的差异贡献

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摘要

Essential features of the world are often hidden and must be inferred by constructing internal models based on indirect evidence. Here, to study the mechanisms of inference, we establish a foraging task that is naturalistic and easily learned yet can distinguish inference from simpler strategies such as the direct integration of sensory data. We show that both mice and humans learn a strategy consistent with optimal inference of a hidden state. However, humans acquire this strategy more than an order of magnitude faster than mice. Using optogenetics in mice, we show that orbitofrontal and anterior cingulate cortex inactivation impacts task performance, but only orbitofrontal inactivation reverts mice from an inference-based to a stimulus-bound decision strategy. These results establish a cross-species paradigm for studying the problem of inference-based decision making and begins to dissect the network of brain regions crucial for its performance.
机译:世界的基本特征通常是隐藏的,必须通过基于间接证据构建内部模型来推断。 在这里,要研究推理的机制,我们建立了一个伪造的任务,它是自然主义的,很容易学习,但可以区分推断从更简单的策略,例如直接集成感官数据。 我们表明,两只老鼠和人类都学习了一种与隐藏状态最佳推理一致的策略。 然而,人类比小鼠更快地获得超过一个数量级的策略。 在小鼠中使用邻丙替莫,我们表明眶内和前型铰接皮质灭活影响任务性能,但只有胰敌对的失活恢复了基于推断的刺激决策策略的小鼠。 这些结果建立了一种用于研究基于推理的决策问题的跨物种范例,并开始解剖脑区网络至关重要的性能。

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  • 来源
    《Neuron》 |2020年第1期|共17页
  • 作者单位

    Champalimaud Ctr Unknown Champalimaud Res P-1400038 Lisbon Portugal;

    Hebrew Univ Jerusalem Edmond &

    Lily Safra Ctr Brain Sci Edmond J Safra Campus IL-91904 Jerusalem;

    Champalimaud Ctr Unknown Champalimaud Res P-1400038 Lisbon Portugal;

    Champalimaud Ctr Unknown Champalimaud Res P-1400038 Lisbon Portugal;

    MIT Dept Brain &

    Cognit Sci 77 Massachusetts Ave Room 46-2005 Cambridge MA 02139 USA;

    Champalimaud Ctr Unknown Champalimaud Res P-1400038 Lisbon Portugal;

    Univ Amsterdam Fac Sci Swammerdam Inst Life Sci Cognit &

    Syst Neurosci Grp NL-1098 XH Amsterdam;

    Champalimaud Ctr Unknown Champalimaud Res P-1400038 Lisbon Portugal;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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