...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Inhibitory Control of Prefrontal Cortex by the Claustrum
【24h】

Inhibitory Control of Prefrontal Cortex by the Claustrum

机译：克劳斯抑制预填充性皮层的控制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The claustrum is a small subcortical nucleus that has extensive excitatory connections with many cortical areas. While the anatomical connectivity from the claustrum to the cortex has been studied intensively, the physiological effect and underlying circuit mechanisms of claustrocortical communication remain elusive. Here we show that the claustrum provides strong, widespread, and long-lasting feedforward inhibition of the prefrontal cortex (PFC) sufficient to silence ongoing neural activity. This claustrocortical feedforward inhibition was predominantly mediated by interneurons containing neuropeptide Y, and to a lesser extent those containing parvalbumin. Therefore, in contrast to other long-range excitatory inputs to the PFC, the claustrocortical pathway is designed to provide overall inhibition of cortical activity. This unique circuit organization allows the claustrum to rapidly and powerfully suppress cortical networks and suggests a distinct role for the claustrum in regulating cognitive processes in prefrontal circuits.
机译：Claustrum是一个小的皮质核，具有与许多皮质区域具有广泛的兴奋联系。虽然已经集中研究了从克劳师到皮层的解剖连接，但是珀斯致景通信的生理效应和潜在的电路机制仍然难以捉摸。在这里，我们表明，克劳斯特提供了足以沉默持续神经活动的前额叶皮质（PFC）的强烈，广泛和持久的前馈抑制。该围绕型馈波抑制抑制主要由含有神经肽Y的中间核来介导的，并且在较小程度上介导含有帕瓦耳蛋白的较小程度。因此，与PFC的其他远程兴奋性输入相反，围绕族质途径设计以提供对皮质活性的总体抑制。这种独特的电路组织允许Claustrum快速且有力地抑制皮质网络，并对克劳斯特在调节前额级电路中的认知过程中的不同作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号