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首页> 外文期刊>Neuron >Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation
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Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation

机译:在眼睛开口之前的光促进视网膜波和特定于眼的偏析

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摘要

Retinal waves are bursts of correlated activity that occur prior to eye opening and provide a critical source of activity that drives the refinement of retinofugal projections. Retinal waves are thought to be initiated spontaneously with their spatiotemporal features dictated by immature neural circuits. Here we demonstrate that, during the second postnatal week in mice, changes in light intensity dictate where and when a subset of retinal waves are triggered via activation of conventional photoreceptors. Propagation properties of triggered waves are indistinguishable from spontaneous waves, indicating that they are activating the same retinal circuits. Using whole-brain imaging techniques, we demonstrate that light deprivation prior to eye opening diminishes eye-specific segregation of the retinal projections to the dorsolateral geniculate nucleus of the thalamus, but not other retinal targets. These data indicate that light that passes through the closed eyelids plays a critical role in the development of the image-forming visual system.
机译:视网膜波是在眼睛开口之前发生的相关活性的突发,并提供驱动视网戊上腺突出的细化的关键活动来源。认为视网膜波被自发地启动,其时尚特征由不成熟的神经电路决定。在这里,我们证明,在小鼠的第二个后一周期间,光强度的变化决定通过传统光感受器的激活触发视网膜波的子集。触发波的传播特性与自发的波无法区分,表明它们激活相同的视网膜电路。使用全脑成像技术,我们证明眼睛开口前的缺陷剥夺将视网膜突出的眼睛特异性分离减少到丘脑的背侧凝固核,但不是其他视网膜靶标。这些数据表明穿过封闭眼睑的光在图像形成视觉系统的开发中起着关键作用。

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  • 来源
    《Neuron》 |2018年第5期|共11页
  • 作者单位

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Sch Optometry Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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