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Location and Plasticity of the Sodium Spike Initiation Zone in Nociceptive Terminals In Vivo

机译：体内伤害终端钠穗起始区的位置和可塑性

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摘要

Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive terminals in vivo convert noxious stimuli into propagating signals. By monitoring noxiousstimulus-induced Ca2+ dynamics from mouse corneal terminals, we found that initiation of Na+ channel (Nav)-dependent propagating signals takes place away from the terminal and that the starting point for Nav-mediated propagation depends on Nay functional availability. Acute treatment with the proinflammatory cytokines tumor necrosis factor a (TNF-alpha) and interleukin 1 beta (IL-1 beta) resulted in a shift of the location of Nay involvement toward the terminal, thus increasing nociceptive excitability. Moreover, a shift of Nay involvement toward the terminal occurs in corneal hyperalgesia resulting from acute photokeratitis. This dynamic change in the location of Nay-mediated propagation initiation could underlie pathological pain hypersensitivity.
机译：伤害终端具有用于检测，传输和调节有毒信号的元件，从而为疼痛感应枢转。尽管如此，终端在生理条件下的转导过程的功能描述尚未完全实现。在这里，我们研究了Vivo中的伤害终端如何将有害刺激转换为传播信号。通过监测来自小鼠角膜终端的NoxiousTumulus诱导的CA2 +动力学，我们发现Na +信道（NAV） - 依存传播信号的启动远离终端，并且导航传播的起点取决于NAY功能可用性。用促炎细胞因子肿瘤坏死因子A（TNF-α）和白细胞介素1β（IL-1β）的急性治疗导致NAY的位置偏移朝向末端的偏移，从而增加了伤害性兴奋性。此外，NAY参与末端的偏移发生在由急性光电技术炎导致的角膜痛觉中发生。 NAY介导的繁殖开始的位置的这种动态变化可能是病理疼痛超敏反应。

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  • 来源
    《Neuron》 |2019年第4期|共17页
  • 作者

    Goldstein Robert H.; Barkai Omer; Inigo-Portugues Almudena; Katz Ben; Lev Shaya; Binshtok Alexander M.;

  • 作者单位

    Hebrew Univ Jerusalem Fac Med Inst Med Res Israel Canada Dept Med Neurobiol IL-9112001;

    Hebrew Univ Jerusalem Fac Med Inst Med Res Israel Canada Dept Med Neurobiol IL-9112001;

    Univ Miguel Hernandez CSIC Inst Neurociencias Alacant 03550 Spain;

    Hebrew Univ Jerusalem Fac Med Inst Med Res Israel Canada Dept Med Neurobiol IL-9112001;

    Hebrew Univ Jerusalem Fac Med Inst Med Res Israel Canada Dept Med Neurobiol IL-9112001;

    Hebrew Univ Jerusalem Fac Med Inst Med Res Israel Canada Dept Med Neurobiol IL-9112001;

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  • 正文语种 eng
  • 中图分类 神经病学;
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