...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Activity of Prefrontal Neurons Predict Future Choices during Gambling
【24h】

Activity of Prefrontal Neurons Predict Future Choices during Gambling

机译：前额外神经元的活性预测赌博过程中的未来选择

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neuronal signals in the prefrontal cortex have been reported to predict upcoming decisions. Such activity patterns are often coupled to perceptual cues indicating correct choices or values of different options. How does the prefrontal cortex signal future decisions when no cues are present but when decisions are made based on internal valuations of past experiences with stochastic outcomes? We trained rats to perform a two-arm bandit-task, successfully adjusting choices between certain-small or possible-big rewards with changing long-term advantages. We discovered specialized prefrontal neurons, whose firing during the encounter of no-reward predicted the subsequent choice of animals, even for unlikely or uncertain decisions and several seconds before choice execution. Optogenetic silencing of the prelimbic cortex exclusively timed to encounters of no reward, provoked animals to excessive gambling for large rewards. Firing of prefrontal neurons during outcome evaluation signals subsequent choices during gambling and is essential for dynamically adjusting decisions based on internal valuations.
机译：据报道，前额叶皮质中的神经元信号预测即将到来的决策。这种活动模式通常耦合到具有指示正确选择或不同选项的值的感知线索。在没有提示的情况下，预先转移性皮质信号如何决定，但是当根据过去经历的内部估值而做出决定时？我们培训了大鼠进行双臂强盗任务，成功地调整某些小或可能的大奖励之间的选择，改变了长期优势。我们发现了专门的前额外神经元，其在遇到无奖励期间的射击预测了随后的动物选择，即使是不太可能或不确定的决定和在选择执行前几秒钟。 Prelimbic Cortex的光学沉默专门定时遇到没有奖励，激起动物以过度赌博进行大型奖励。在观众评估期间射击前额外神经元在赌博过程中的后续选择，对于基于内部估值的决策是必不可少的。

著录项

  • 来源
    《Neuron》 |2019年第1期|共20页
  • 作者

    Passecker Johannes; Mikus Nace; Malagon-Vina Hugo; Anner Philip; Dimidschstein Jordane; Fishell Gordon; Dorffner Georg; Klausberger Thomas;

  • 作者单位

    Med Univ Vienna Div Cognit Neurobiol Ctr Brain Res Vienna Austria;

    Med Univ Vienna Div Cognit Neurobiol Ctr Brain Res Vienna Austria;

    Med Univ Vienna Div Cognit Neurobiol Ctr Brain Res Vienna Austria;

    Med Univ Vienna Div Cognit Neurobiol Ctr Brain Res Vienna Austria;

    NYU Sch Med Inst Neurosci New York NY USA;

    NYU Sch Med Inst Neurosci New York NY USA;

    Med Univ Vienna Ctr Med Stat Informat &

    Intelligent Syst Vienna Austria;

    Med Univ Vienna Div Cognit Neurobiol Ctr Brain Res Vienna Austria;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号