Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze

Xu Haibing; Baracskay Peter; ONeill Joseph; Csicsvari Jozsef

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Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze

机译：海马CA1放置细胞的组装响应预测径向八臂迷宫上的目标定向空间任务中的学习行为

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Hippocampus is needed for both spatial working and reference memories. Here, using a radial eight-arm maze, we examined how the combined demand on these memories influenced CA1 place cell assemblies while reference memories were partially updated. This was contrasted with control tasks requiring only working memory or the update of reference memory. Reference memory update led to the reward-directed place field shifts at newly rewarded arms and to the gradual strengthening of firing in passes between newly rewarded arms but not between those passes that included a familiar-rewarded arm. At the maze center, transient network synchronization periods preferentially replayed trajectories of the next chosen arm in reference memory tasks but the previously visited arm in the working memory task. Hence, reference memory demand was uniquely associated with a gradual, goal novelty-related reorganization of place cell assemblies and with trajectory replay that reflected the animal's decision of which arm to visit next.

机译：空间工作和参考存储器需要海马。在这里，使用径向八臂迷宫，我们检查了如何对这些存储器的组合需求是如何影响CA1的电池组件，而参考存储器部分更新。这与仅需要工作存储器或参考存储器的更新的控制任务对比。参考记忆更新导致新奖励武器的奖励定向场地偏移，并逐渐加强在新奖励的怀抱之间的通过，但不在包括熟悉奖励的手臂之间的传递之间。在迷宫中心，瞬态网络同步时段优先重放下一个所选择的臂的轨迹，其中参考存储器任务，但先前访问的手臂在工作存储器任务中。因此，参考记忆需求与渐进的目标新颖的与地方电池组件和轨迹重播有关的逐步相关，并反映了动物的决定下一个手臂的决定。

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《Neuron》 |2019年第1期|共18页
作者
Xu Haibing; Baracskay Peter; ONeill Joseph; Csicsvari Jozsef;
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IST Austria Campus 1 A-3400 Klosterneuburg Austria;

IST Austria Campus 1 A-3400 Klosterneuburg Austria;

IST Austria Campus 1 A-3400 Klosterneuburg Austria;

IST Austria Campus 1 A-3400 Klosterneuburg Austria;

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正文语种 eng
中图分类神经病学;
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1. Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze [J] . Xu Haibing, Baracskay Peter, ONeill Joseph, Neuron . 2019,第1期

机译：海马CA1放置细胞的组装响应预测径向八臂迷宫上的目标定向空间任务中的学习行为
2. Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats. [J] . Masuoka T, Fujii Y, Kamei C European Journal of Pharmacology: An International Journal . 2006,第1a2期

机译：东pol碱对八臂radial骨迷宫任务大鼠海马θ节律的影响。
3. Effect of Polygala tenuifolia Root Extract on Scopolamine-Induced Impairment of Rat Spatial Cognition in an Eight-Arm Radial Maze Task [J] . Xiu-Lan SUN, Hideyuki Iro, Takayoshi MASUOKA Biological & pharmaceutical bulletin . 2007,第9期

机译：远志根提取物对东A碱诱导的八臂径向迷宫任务大鼠空间认知障碍的影响。
4. A model of predictive learning in the rat hippocampal principal cells during spatial activity [C] . Denham, M.J., McCabe, . 1998

机译：大鼠空间活动期间海马主细胞的预测性学习模型
5. Effects of PD149163 on spatial working and reference memory in rats performing a radial arm maze task [D] . Donegan, Maureen Suzanne 2011

机译：PD149163对执行a臂迷宫任务的大鼠空间工作和参考记忆的影响
6. Histamine H1 receptor knockout mice exhibit impaired spatial memory in the eight-arm radial maze [O] . A Zlomuzica, LA Ruocco, AG Sadile, 2009

机译：组胺H1受体敲除小鼠在八臂径向迷宫中显示出受损的空间记忆
7. Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze [O] . Haibing Xu, Peter Baracskay, Joseph O’Neill, 2019

机译：海马CA1的装配反应将径向八臂迷宫上的目标定向空间任务中的学习行为预测

Assembly Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze

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