Loss of Na(V)1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability

Kaczmarek Leonard K.

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Loss of Na(V)1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability

机译：Denrites中的Na（v）1.2依赖性背交作用潜力有助于自闭症和智力残疾

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Mutations in voltage-dependent sodium channels cause severe autism/intellectual disability. In this issue of Neuron, Spratt et al. (2019) show that lowering expression of Nav1.2 channels attenuates backpropagation of action potentials into dendrites of cortical neurons, preventing spike-timing-dependent synaptic plasticity.

机译：电压依赖性钠通道中的突变导致严重的自闭症/智力残疾。在这个神经元，Spratt等人的问题中。（2019）表明，降低NAV1.2的表达频道衰减了对皮质神经元的树突，防止尖峰定时突触可塑性的突出动作电位。

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《Neuron》 |2019年第4期|共4页
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Kaczmarek Leonard K.;
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Yale Univ Sch Med Dept Pharmacol New Haven CT 06520 USA;

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正文语种 eng
中图分类神经病学;
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1. Loss of Na(V)1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability [J] . Kaczmarek Leonard K. Neuron . 2019,第4期

机译：Denrites中的Na（v）1.2依赖性背交作用潜力有助于自闭症和智力残疾
2. Differential cholinergic modulation of Ca2+ transients evoked by backpropagating action potentials in apical and basal dendrites of cortical pyramidal neurons. [J] . Cho KH, Jang HJ, Lee EH, Journal of Neurophysiology . 2008,第6期

机译：Ca2 +瞬态的差异胆碱能调制由皮层锥体神经元的根和树突的反向传播动作电位引起。
3. Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. [J] . Christie JM, Westbrook GL Journal of Neurophysiology . 2003,第5期

机译：通过A型钾电流调节二尖瓣细胞外侧树突中的反向传播动作电位。
4. Talk to Me: The Role of Human-Robot Interaction in Improving Verbal Communication Skills in Students with Autism or Intellectual Disability [C] . David Silvera-Tawil, DanaKai Bradford, Christine Roberts-Yates IEEE International Symposium on Robot and Human Interactive Communication . 2018

机译：与我对话：人机交互在提高自闭症或智障学生口头交流能力中的作用
5. Spike timing-dependent plasticity and backpropagating action potentials: A modeling study. [D] . Acker, Corey Derek. 2005

机译：尖峰时序相关的可塑性和向后传播的动作电位：模型研究。
6. Collybistin binds and inhibits mTORC1 signaling: a potential novel mechanism contributing to intellectual disability and autism [O] . Camila Oliveira Freitas Machado, Karina Griesi-Oliveira, Carla Rosenberg, 2016

机译：Collbisbistin结合并抑制mTORC1信号传导：潜在的新型机制导致智力残疾和自闭症
7. Differential Cholinergic Modulation of Ca 2 � Transients Evoked by Backpropagating Action Potentials in Apical and Basal Dendrites of Cortical [O] . Kwang-hyun Cho, Hyun-jong Jang, Eun-hui Lee, 2013

机译：皮质顶端和基底树突中反向传导电位诱发Ca 2 +瞬变的差异胆碱能调节
8. Genetic Testing for Developmental Disabilities, Intellectual Disability, and Autism Spectrum Disorder. Technical Brief Number 23. [R] . 2015

机译：发育障碍，智力残疾和自闭症谱系障碍的基因检测。技术摘要第23号。

Loss of Na(V)1.2-Dependent Backpropagating Action Potentials in Dendrites Contributes to Autism and Intellectual Disability

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