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首页> 外文期刊>Neuron >Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall
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Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall

机译：海马Ca3金字塔神经元内部性质，连通性和再现在记忆召回时的促突

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摘要

The hippocampal CA3 region is classically viewed as a homogeneous autoassociative network critical for associative memory and pattern completion. However, recent evidence has demonstrated a striking heterogeneity along the transverse, or proximodistal, axis of CA3 in spatial encoding and memory. Here we report the presence of striking proximodistal gradients in intrinsic membrane properties and synaptic connectivity for dorsal CA3. A decreasing gradient of mossy fiber synaptic strength along the proximodistal axis is mirrored by an increasing gradient of direct synaptic excitation from entorhinal cortex. Furthermore, we uncovered a nonuniform pattern of reactivation of fear memory traces, with the most robust reactivation during memory retrieval occurring in mid-CA3 (CA3b), the region showing the strongest net recurrent excitation. Our results suggest that heterogeneity in both intrinsic properties and synaptic connectivity may contribute to the distinct spatial encoding and behavioral role of CA3 subregions along the proximodistal axis.
机译：海马CA3区域经典视为均匀的自动关联网络，适用于关联内存和模式完成。然而，最近的证据表明，在空间编码和记忆中，沿横向或倾角轴的CA3轴的截味的异质性证明了一种醒目的异质性。在这里，我们在内在膜性能和背部Ca3的突触连接中报告存在醒目的替代梯度梯度。沿着探针轴轴沿着探针轴的渐近突触强度的梯度降低，通过来自Entorhinal皮质的直接突触激发的梯度增加。此外，我们发现恐惧记忆迹线的恐惧记忆迹线的不均匀模式，在中部CA3（CA3B）中发生的存储器检索期间具有最稳健的再活化，该区域显示最强的净复发激发。我们的结果表明，内在特性和突触连接中的异质性可以有助于沿着探针轴的CA3子区域的不同空间编码和行为作用。

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