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首页> 外文期刊>Neuron >Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila
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Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila

机译：Serotonergic调制使果蝇在果蝇的显影感应电路中能够特异性可塑性

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摘要

How experiences during development cause long-lasting changes in sensory circuits and affect behavior in mature animals are poorly understood. Here we establish a novel system for mechanistic analysis of the plasticity of developing neural circuits by showing that sensory experience during development alters nociceptive behavior and circuit physiology in Drosophila larvae. Despite the convergence of nociceptive and mechanosensory inputs on common second-order neurons (SONs), developmental noxious input modifies transmission from nociceptors to their SONs, but not from mechanosensors to the same SONs, which suggests striking sensory pathway specificity. These SONs activate serotonergic neurons to inhibit nociceptor-to-SON transmission; stimulation of nociceptors during development sensitizes nociceptor presynapses to this feedback inhibition. Our results demonstrate that, unlike associative learning, which involves inputs from two sensory pathways, sensory pathway-specific plasticity in the Drosophila nociceptive circuit is in part established through feedback modulation. This study elucidates a novel mechanism that enables pathway-specific plasticity in sensory systems.
机译：在开发过程中的经验导致感官电路的长期变化，并且在成熟的动物中影响行为都很清楚。在这里，我们通过表明开发过程中的感觉体验改变了侏儒的伤害性行为和狼人幼虫的感觉行为和循环生理学来建立一种新颖的制动力学分析。尽管在普通二阶神经元（儿子）上的伤害和机械感染的收敛性，但发育有害输入会改变从伤害者到他们的儿童的传播，但不是从机械传感器到同一儿子，这表明醒目的感觉途径特异性。这些儿子激活血清onoonergic神经元以抑制伤害者到儿子的传播;在发育过程中刺激伤害者敏感伤害者预先染色的伤害者对该反馈抑制。我们的结果表明，与联想学习不同，这涉及来自两个感官途径的输入，果蝇伤害电路中的感觉途径特异性可塑性部分是通过反馈调制建立的部分。该研究阐明了一种新的机制，使得感觉系统中的途径特异性可塑性能够。

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  • 来源
    《Neuron》 |2017年第3期|共20页
  • 作者

    Kaneko Takuya; Macara Ann Marie; Li Ruonan; Hu Yujia; Iwasaki Kenichi; Dunnings Zane; Firestone Ethan; Horvatic Shawn; Guntur Ananya; Shafer Orie T.; Yang Chung-Hui; Zhou Jie; Ye Bing;

  • 作者单位

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

    Northern Illinois Univ Dept Comp Sci De Kalb IL 60115 USA;

    Duke Univ Sch Med Dept Neurobiol Durham NC 27710 USA;

    Univ Michigan Dept Mol Cellular &

    Dev Biol Ann Arbor MI 48109 USA;

    Duke Univ Sch Med Dept Neurobiol Durham NC 27710 USA;

    Northern Illinois Univ Dept Comp Sci De Kalb IL 60115 USA;

    Univ Michigan Inst Life Sci Ann Arbor MI 48109 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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