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Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

机译:Amygdala电路中的突触塑性,倾向,倾向和网络振荡,用于存储和检索情绪记忆

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摘要

The neuronal circuits of the basolateral amygdala (BLA) are crucial for acquisition, consolidation, retrieval, and extinction of associative emotional memories. Synaptic plasticity in BLA neurons is essential for associative emotional learning and is a candidate mechanism through which subsets of BLA neurons (commonly termed "engram'') are recruited during learning and reactivated during memory retrieval. In parallel, synchronous oscillations in the theta and gamma bands between the BLA and interconnected structures have been shown to occur during consolidation and retrieval of emotional memories. Understanding how these cellular and network phenomena interact is vital to decipher the roles of emotional memory formation and storage in the healthy and pathological brain. Here, we review data on synaptic plasticity, engrams, and network oscillations in the rodent BLA. We explore mechanisms through which synaptic plasticity, engrams, and long-range synchrony might be interconnected.
机译:基底间杏仁达拉(BLA)的神经元电路对于收购,整合,检索和灭绝联想情绪记忆至关重要。 BLA神经元中的突触塑性对于关联情绪学习至关重要,并且是在学习期间招募BLA神经元的子集(通常称为“engram”)的候选机制,在存储器检索期间重新激活。在θ和伽马中并行,同步振荡 在整合和检索情绪存储器期间已经显示了BLA和互连结构之间的带。了解这些细胞和网络现象的互动是如何破译情绪记忆形成和储存在健康和病理大脑中的作用至关重要。在这里,我们 审查啮齿动物BLA中突触塑性,倾向,倾向,倾向和网络振荡的数据。我们探讨了突触可塑性,倾向,倾向和远程同步可能相互连接的机制。

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  • 来源
    《Neuron》 |2017年第4期|共13页
  • 作者单位

    Univ Oxford Dept Pharmacol Mansfield Rd Oxford OX1 3TH England;

    Aarhus Univ Dept Biomed Nord EMBL Partnership Mol Med Danish Res Inst Translat Neurosci DANDRITE;

    Aarhus Univ Dept Biomed Nord EMBL Partnership Mol Med Danish Res Inst Translat Neurosci DANDRITE;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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