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Slip-Based Coding of Local Shape and Texture in Mouse S1

机译:鼠标S1中局部形状和纹理的滑动编码

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摘要

Tactile objects have both local geometry (shape) and broader macroscopic texture, but how these different spatial scales are simultaneously encoded during active touch is unknown. In the whisker system, we tested for a shared code based on localized whisker micromotions (stick-slips) and slip-evoked spikes. We trained mice to discriminate smooth from rough surfaces, including ridged gratings and sandpaper. Whisker slips locked to ridges and evoked temporally precise spikes (10 ms jitter) in somatosensory cortex (S1) that could resolve ridges with similar to 1 mm accuracy. Slip-sensitive neurons also encoded touch and texture. On rough surfaces, both slip-evoked spikes and an additional non-slip signal elevated mean firing rate, allowing accurate rough-smooth texture decoding from population firing rate. Eighteen percent of neurons were selective among rough surfaces. Thus, slips elicit spatially and temporally precise spiking in S1 that simultaneously encodes local shape (ridges) and is integrated into a macroscopic firing rate code for roughness.
机译:触觉对象具有本地几何形状(形状)和更广泛的宏观纹理,但如何在活动触摸期间同时编码这些不同的空间尺度是未知的。在晶须系统中,我们基于本地化的晶须微调(Stick-Slips)和滑动诱发的尖峰测试了共享代码。我们培训了小鼠,以区分从粗糙表面光滑,包括脊柱和砂纸。晶须滑动锁定到脊状物,并在躯体感应皮层中唤起时间上精确的尖峰(S1),可以解析与1 mm精度相似的脊。滑动敏感神经元也编码了触摸和纹理。在粗糙的表面上,滑动诱发的尖峰和额外的防滑信号升高的平均烧制率,允许从人口射击率准确地粗糙化纹理解码。粗糙表面中的18%的神经元是选择性的。因此,在同时编码局部形状(脊)的S1中,在S1中引出的滑动和时间精确的尖峰,并且被集成到粗糙度的宏观点火率代码中。

著录项

  • 来源
    《Neuron》 |2018年第2期|共21页
  • 作者单位

    Univ Calif Berkeley Helen Wills Neurosci Inst Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

    Univ Calif Berkeley Dept Mol &

    Cell Biol Berkeley CA 94720 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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