Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point

Peng Jimmy; Fabre Pierre J.; Dolique Tiphaine; Swikert Shannon M.; Kermasson Laetitia; Shimogori Tomomi; Charron Frederic

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Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point

机译：Sonic Hedgehog是一种远程制作的提示，可在中线选择点控制轴突上的轴突

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At the optic chiasm choice point, ipsilateral retinal ganglion cells (RGCs) are repelled away from the midline by guidance cues, including Ephrin-B2 and Sonic Hedgehog (Shh). Although guidance cues are normally produced by cells residing at the choice point, the mRNA for Shh is not found at the optic chiasm. Here we show that Shh protein is instead produced by contralateral RGCs at the retina, transported anterogradely along the axon, and accumulates at the optic chiasm to repel ipsilateral RGCs. In vitro, contralateral RGC axons, which secrete Shh, repel ipsilateral RGCs in a Boc- and Smo-dependent manner. Finally, knockdown of Shh in the contralateral retina causes a decrease in the proportion of ipsilateral RGCs in a non-cell-autonomous manner. These findings reveal a role for axon-axon interactions in ipsilateral RGC guidance, and they establish that remotely produced cues can act at axon guidance midline choice points.

机译：在光学Chiasm选择点，Iphrin-B2和Sonic Hedgehog（SHH）包括ephrin-B2和Song刺猬（SHH），在光学Chiasm选择点中，远离中线被排斥来自中线的击退。尽管导向提示通常由居选择点的细胞产生，但是在光学Chiasm中找不到SHH的mRNA。在这里，我们表明SHH蛋白是通过视网膜的对侧RGC制造的，沿着轴突运输，并在光学赤壁上积聚以排斥同侧RGC。体外，对侧RGC轴突，其分泌SHH，以Boc-and Smo依赖的方式释放IpsilidallAtal RGCS。最后，对侧视网膜中的SHH的敲低导致非细胞自主方式的同侧RGC的比例降低。这些调查结果揭示了轴突 - 轴突相互作用在IPsilidal RGC指导中的作用，它们建立了远程产生的提示可以在轴突引导中线选择点采取行动。

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《Neuron》 |2018年第2期|共19页
作者
Peng Jimmy; Fabre Pierre J.; Dolique Tiphaine; Swikert Shannon M.; Kermasson Laetitia; Shimogori Tomomi; Charron Frederic;
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Montreal Clin Res Inst IRCM 110 Pine West Ave Montreal PQ H2W 1R7 Canada;

Montreal Clin Res Inst IRCM 110 Pine West Ave Montreal PQ H2W 1R7 Canada;

Montreal Clin Res Inst IRCM 110 Pine West Ave Montreal PQ H2W 1R7 Canada;

Montreal Clin Res Inst IRCM 110 Pine West Ave Montreal PQ H2W 1R7 Canada;

Montreal Clin Res Inst IRCM 110 Pine West Ave Montreal PQ H2W 1R7 Canada;

RIKEN Brain Sci Inst Wako Saitama 3510198 Japan;

Montreal Clin Res Inst IRCM 110 Pine West Ave Montreal PQ H2W 1R7 Canada;

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中图分类神经病学;
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1. Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point [J] . Peng Jimmy, Fabre Pierre J., Dolique Tiphaine, Neuron . 2018,第2期

机译：Sonic Hedgehog是一种远程制作的提示，可在中线选择点控制轴突上的轴突
2. 14-3-3 Proteins Regulate a Cell-Intrinsic Switch from Sonic Hedgehog-Mediated Commissural Axon Attraction to Repulsion after Midline Crossing [J] . YamP., KentC., MorinS., Neuron . 2012,第4期

机译：14-3-3蛋白质调节中线穿越后从声波刺猬介导的连合轴突吸引向排斥的细胞内在转换。
3. Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing. [J] . Parra LM, Zou Y Nature neuroscience . 2010,第1期

机译：声波刺猬在中线穿越期间诱导连合轴突对信号量排斥的反应。
4. Controlled Delivery of Sonic Hedgehog Morphogen for Cardiac Repair [C] . Noah Johnson, Maritza Kruger, Neil Davies, Society for Biomaterials annual meeting and exposition . 2014

机译：用于心脏修复的声波刺猬蛋白的受控递送
5. In Vivo Structure-function Analysis of Drosophila Robo1, an Axon Guidance Receptor Critical for Midline Repulsive Signaling in the Embryonic Central Nervous System [D] . Brown, Haley. 2018

机译：在果蝇Robo1的体内结构函数分析中，胚胎中枢神经系统中线排斥信令至关重要的轴突引导受体
6. Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance [O] . Evelyn C. Avilés, Nicole H. Wilson, Esther T. Stoeckli 2013

机译：声波刺猬和Wnt：形态发生中的拮抗剂但在轴突指导中的合作者
7. The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance [O] . Charron Frédéric, Stein Elke, Jeong Juhee, 2003

机译：Morphogen Sonic Hedgehog是一种轴突趋化因子，在中线轴突指导中与Netrin-1协同作用

Sonic Hedgehog Is a Remotely Produced Cue that Controls Axon Guidance Trans-axonally at a Midline Choice Point

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