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首页> 外文期刊>Neuron >Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control
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Graded Arrays of Spinal and Supraspinal V2a Interneuron Subtypes Underlie Forelimb and Hindlimb Motor Control

机译：脊柱和求峰值阵阵阵列底座亚型底部强制外部底部和后肢电机控制

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摘要

The spinal cord contains neural networks that enable regionally distinct motor outputs along the body axis. Nevertheless, it remains unclear how segment-specific motor computations are processed because the cardinal interneuron classes that control motor neurons appear uniform at each level of the spinal cord. V2a interneurons are essential to both forelimb and hindlimb movements, and here we identify two major types that emerge during development: type I neurons marked by high Chx10 form recurrent networks with neighboring spinal neurons and type II neurons that downregulate Chx10 and project to supraspinal structures. Types I and II V2a interneurons are arrayed in counter-gradients, and this network activates different patterns of motor output at cervical and lumbar levels. Single-cell RNA sequencing (RNA-seq) revealed type I and II V2a neurons are each comprised of multiple subtypes. Our findings uncover a molecular and anatomical organization of V2a interneurons reminiscent of the orderly way motor neurons are divided into columns and pools.
机译：脊髓包含神经网络，可沿着主体轴线使区域不同的电动机输出。然而，它仍然不明确于处理分段特定的电动机计算，因为控制电动机神经元在脊髓的每个级别出现均匀的红衣主教的中间核课程。 V2A Interneurons对Forelimb和Hindlimb运动既是必不可少的，这里我们识别出现在开发期间出现的两种主要类型：由高CHX10标记的I型神经元与相邻脊髓神经元和II型神经元形成经常性网络，使得CHX10下调CHX10和II型神经元。类型I和II V2A Interneurons在反梯度中排列，该网络在颈椎和腰部水平下激活不同的电机输出模式。单细胞RNA测序（RNA-SEQ）显示I型和II V2A神经元均由多个亚型组成。我们的研究结果揭示了V2A Interneurons的分子和解剖组织，让您联想到有序的方式，电机神经元分为柱子和池。

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  • 来源
    《Neuron》 |2018年第4期|共21页
  • 作者

    Hayashi Marito; Hinckley Christopher A.; Driscoll Shawn P.; Moore Niall J.; Levine Ariel J.; Hilde Kathryn L.; Sharma Kamal; Pfaff Samuel L.;

  • 作者单位

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

    Univ Illinois Dept Anat &

    Cell Biol 808 South Wood St Chicago IL 60612 USA;

    Salk Inst Biol Studies Gene Express Lab 10010 North Torrey Pines La Jolla CA 92037 USA;

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  • 正文语种 eng
  • 中图分类 神经病学;
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