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首页> 外文期刊>Neuron >The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations
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The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations

机译：基础前脑调节全球休息状态FMRI波动

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摘要

Patterns of spontaneous brain activity, typically measured in humans at rest with fMRI, are used routinely to assess the brain's functional organization. The mechanisms that generate and coordinate the underlying neural fluctuations are largely unknown. Here we investigate the hypothesis that the nucleus basalis of Meynert (NBM), the principal source of widespread cholinergic and GABAergic projections to the cortex, contributes critically to such activity. We reversibly inactivated two distinct sites of the NBM in macaques while measuring fMRI activity across the brain. We found that inactivation led to strong, regionalized suppression of shared or "global'' signal components of cortical fluctuations ipsilateral to the injection. At the same time, the commonly studied resting-state networks retained their spatial structure under this suppression. The results indicate that the NBM contributes selectively to the global component of functional connectivity but plays little if any role in the specific correlations that define resting-state networks.
机译：自发性脑活动模式，通常用FMRI休息的人类测量，常常用于评估大脑的功能组织。产生和协调潜在的神经波动的机制在很大程度上是未知的。在这里，我们调查了Meynert（NBM），广泛胆碱能和胃肠杆菌突出的主要来源对皮质的假设，对这些活性有贡献。我们在猕猴中可逆地灭活了两种不同的NBM位点，同时在大脑上测量FMRI活动。我们发现，灭活导致皮质波动的共享或“全球”信号组件的强烈，区域化抑制的皮质波动同侧对注射。同时，常用的静态网络在这种抑制下保留了它们的空间结构。结果表明NBM为功能连接的全局组件有助于，但如果在定义休息状态网络的具体相关性中，则效果很少。

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  • 来源
    《Neuron》 |2018年第4期|共17页
  • 作者

    Turchi Janita; Chang Catie; Ye Frank Q.; Russ Brian E.; Yu David K.; Cortes Carlos R.; Monosov Ilya E.; Duyn Jeff H.; Leopold David A.;

  • 作者单位

    NIMH Neuropsychol Lab NIH Bethesda MD 20892 USA;

    NINDS Lab Funct &

    Mol Imaging NIH Bethesda MD 20892 USA;

    NEI Neurophysiol Imaging Facil NIMH NINDS NIH Bethesda MD 20892 USA;

    NIMH Neuropsychol Lab NIH Bethesda MD 20892 USA;

    NEI Neurophysiol Imaging Facil NIMH NINDS NIH Bethesda MD 20892 USA;

    NIAAA Clin Neuroimaging Res Core NIH Bethesda MD 20892 USA;

    Washington Univ Dept Neurosci St Louis MO 63110 USA;

    NINDS Lab Funct &

    Mol Imaging NIH Bethesda MD 20892 USA;

    NIMH Neuropsychol Lab NIH Bethesda MD 20892 USA;

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  • 正文语种 eng
  • 中图分类 神经病学;
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