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Working Memory Enhances Cortical Representations via Spatially Specific Coordination of Spike Times

机译:工作记忆通过空间特定的峰时代的协调增强皮质表示

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摘要

The online maintenance and manipulation of information in working memory (WM) is essential for guiding behavior based on our goals. Understanding how WM alters sensory processing in pursuit of different behavioral objectives is therefore crucial to establish the neural basis of our goal-directed behavior. Here we show that, in the middle temporal (MT) area of rhesus monkeys, the power of the local field potentials in the alpha beta band (8-25 Hz) increases, reflecting the remembered location and the animal's performance. Moreover, the content of WM determines how coherently MT sites oscillate and how synchronized spikes are relative to these oscillations. These changes in spike timing are not only sufficient to carry sensory and memory information, they can also account for WM-induced sensory enhancement. These results provide a mechanistic-level understanding of how WM alters sensory processing by coordinating the timing of spikes across the neuronal population, enhancing the sensory representation of WM targets.
机译:在线维护和操作工作记忆(WM)中的信息对于基于我们的目标来指导行为至关重要。了解WM如何改变追求不同行为目标的感官处理对于建立我们目标定向行为的神经基础是至关重要的。在这里,我们表明,在恒河猴的中间时间(MT)区域,αβBAS带(8-25Hz)中的本地场电位的力量增加,反映了记忆的位置和动物的性能。此外,WM的内容决定了如何连贯的MT站点振荡以及如何同步尖峰相对于这些振荡。 Spike时序的这些变化不仅足以承载感官和内存信息,它们还可以解释WM诱导的感官增强。这些结果提供了对WM如何通过协调神经元群体的尖峰的时序改变感官处理的机械层面的理解,增强了WM靶的感官表示。

著录项

  • 来源
    《Neuron》 |2018年第4期|共19页
  • 作者单位

    Inst Res Fundamental Sci IPM Sch Cognit Sci POB 19395-5746 Tehran Iran;

    Inst Res Fundamental Sci IPM Sch Cognit Sci POB 19395-5746 Tehran Iran;

    Inst Res Fundamental Sci IPM Sch Cognit Sci POB 19395-5746 Tehran Iran;

    Univ Utah Dept Ophthalmol &

    Visual Sci Salt Lake City UT 84132 USA;

    Univ Utah Dept Ophthalmol &

    Visual Sci Salt Lake City UT 84132 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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