Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals

He Yi; Wang Maosen; Chen Xuming; Pohmann Rolf; Polimeni Jonathan R.; Scheffler Klaus; Rosen Bruce R.; Kleinfeld David; Yu Xin

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Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals

机译：超慢单血管大胆和基于CBV的FMRI时尚动力学及其与神经元细胞内钙信号的相关性

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Functional MRI has been used to map brain activity and functional connectivity based on the strength and temporal coherence of neurovascular-coupled hemodynamic signals. Here, single-vessel fMRI reveals vessel-specific correlation patterns in both rodents and humans. In anesthetized rats, fluctuations in the vessel-specific fMRI signal are correlated with the intracellular calcium signal measured in neigh-boring neurons. Further, the blood-oxygen-level-dependent (BOLD) signal from individual venules and the cerebral-blood-volume signal from individual arterioles show correlations at ultra-slow ( 0.1 Hz), anesthetic-modulated rhythms. These data support a model that links neuronal activity to intrinsic oscillations in the cerebral vasculature, with a spatial correlation length of similar to 2 mm for arterioles. In complementary data from awake human subjects, the BOLD signal is spatially correlated among sulcus veins and specified intracortical veins of the visual cortex at similar ultra-slow rhythms. These data support the use of fMRI to resolve functional connectivity at the level of single vessels.

机译：功能性MRI用于基于神经血管耦合血液动力学信号的强度和时间相干来映射脑活动和功能连通性。这里，单船FMRI在啮齿动物和人类中揭示了特定于血管的相关模式。在麻醉大鼠中，血管特异性FMRI信号中的波动与在邻近钻孔神经元中测量的细胞内钙信号相关。此外，来自各个venules的血氧依赖性（粗体）信号和来自个体动脉瘤的脑血体积信号显示在超慢（＆ 0.1 hz），麻醉调制节奏处的相关性。这些数据支持将神经元活动链接到脑脉管系统中的内在振荡的模型，其空间相关长度类似于2mm的动脉溶液。在唤醒人类受试者的互补数据中，粗体信号在空间上与类似的超慢节奏的视觉皮层的特定的肠道内静脉之间相关。这些数据支持FMRI的使用来解决单个船只电平的功能连接。

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《Neuron》 |2018年第4期|共20页
作者
He Yi; Wang Maosen; Chen Xuming; Pohmann Rolf; Polimeni Jonathan R.; Scheffler Klaus; Rosen Bruce R.; Kleinfeld David; Yu Xin;
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Max Planck Inst Biol Cybernet High Field Magnet Resonance Dept D-72076 Tubingen Germany;

Max Planck Inst Biol Cybernet High Field Magnet Resonance Dept D-72076 Tubingen Germany;

Max Planck Inst Biol Cybernet High Field Magnet Resonance Dept D-72076 Tubingen Germany;

Max Planck Inst Biol Cybernet High Field Magnet Resonance Dept D-72076 Tubingen Germany;

Harvard Med Sch Massachusetts Gen Hosp MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi Dept;

Max Planck Inst Biol Cybernet High Field Magnet Resonance Dept D-72076 Tubingen Germany;

Harvard Med Sch Massachusetts Gen Hosp MGH MIT HMS Athinoula A Martinos Ctr Biomed Imagi Dept;

Univ Calif San Diego Dept Phys La Jolla CA 92093 USA;

Max Planck Inst Biol Cybernet High Field Magnet Resonance Dept D-72076 Tubingen Germany;

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中图分类神经病学;
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1. Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals [J] . He Yi, Wang Maosen, Chen Xuming, Neuron . 2018,第4期

机译：超慢单血管大胆和基于CBV的FMRI时尚动力学及其与神经元细胞内钙信号的相关性
2. Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus [J] . Xuming Chen, Filip Sobczak, Yi Chen, Nature Communications . 2019,第1期

机译：用大鼠海马的并发神经元钙录制映射光学出现的单血管FMRI
3. A microfluidic device with spatiotemporal wall shear stress and ATP signals to investigate the intracellular calcium dynamics in vascular endothelial cells [J] . Chen Zong-Zheng, Yuan Wei-Mo, Xiang Cheng, Biomechanics and modeling in mechanobiology . 2019,第1期

机译：具有时空壁剪切应力和ATP信号的微流体装置，以研究血管内皮细胞中的细胞内钙动力学
4. The relationship between time to peak of fMRI-BOLD responses and difficulty of a task suggests neuronal origins to the BOLD contrast [C] . Benito de Celis Alonso Mexican Symposium on Medical Physics . 2012

机译：时间与任务的FMRI-BOLD响应和难度之间的关系表明神经元起源于粗体对比度
5. Spatiotemporal dynamics of low frequency fluctuations in BOLD fMRI [D] . Majeed, Waqas 2011

机译：大胆功能磁共振成像中低频波动的时空动态
6. Ultra-slow single vessel BOLD and CBV-based fMRI spatiotemporal dynamics and their correlation with neuronal intracellular calcium signals [O] . Yi He, Maosen Wang, Xuming Chen, -1

机译：基于超慢速单血管BOLD和CBV的fMRI时空动力学及其与神经元细胞内钙信号的相关性
7. Spatiotemporal dynamics of the BOLD fMRI signals: Toward mapping submillimeter cortical columns using the early negative response [O] . Timothy Q. Duong, Dae-Shik Kim, K�mil U?urbil, 2000

机译：大胆的FMRI信号的时空动态：朝着使用早期负面反应映射淹没的皮质色谱柱

Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals

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