Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons

Hu Wenqin; Bean Bruce P.

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Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons

机译：通过皮质层5的电压依赖性电压控制轴突和体细胞静态潜力的差异控制

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Voltage-dependent conductances not only drive action potentials but also help regulate neuronal resting potential. We found differential regulation of resting potential in the proximal axon of layer 5 pyramidal neurons compared to the soma. Axonal resting potential was more negative than the soma, reflecting differential control by multiple voltage-dependent channels, including sodium channels, Cav3 channels, Kv7 channels, and HCN channels. Kv7 current is highly localized to the axon and HCN current to the soma and dendrite. Because of impedance asymmetry between the soma and axon, axonal Kv7 current has little effect on somatic resting potential, while somatodendritic HCN current strongly influences the proximal axon. In fact, depolarizing somatodendritic HCN current is critical for resting activation of all the other voltage-dependent conductances, including Kv7 in the axon. These experiments reveal complex interactions among voltage-dependent conductances to control region-specific resting potential, with somatodendritic HCN channels playing a critical enabling role.

机译：电压依赖的电导不仅驱动动作电位，而且有助于调节神经元静止电位。我们发现与SOMA相比，我们发现在第5层金字塔神经元的近端轴突中静息潜力的差异调节。轴突静电潜力比SOMA更负，反映多个电压依赖信道的差分控制，包括钠通道，CAV3通道，KV7通道和HCN通道。 KV7电流高度本地化为轴突和HCN电流，进入SOMA和枝晶。由于SOMA和轴突之间的阻抗不对称，轴突KV7电流对体细胞静态潜力几乎没有影响，而Sematodendritic HCN电流会强烈影响近端轴突。实际上，去极化了躯体脱节性HCN电流对于静止所有其他电压依赖性电导的激活，包括KV7的激活至关重要。这些实验揭示了电压依赖性导电之间的复杂相互作用，以控制区域特异性休息潜力，具有躯体统计学HCN通道扮演关键的促使作用。

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《Neuron》 |2018年第6期|共15页
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Hu Wenqin; Bean Bruce P.;
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Harvard Med Sch Dept Neurobiol 220 Longwood Ave Boston MA 02115 USA;

Harvard Med Sch Dept Neurobiol 220 Longwood Ave Boston MA 02115 USA;

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正文语种 eng
中图分类神经病学;
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1. Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons [J] . Hu Wenqin, Bean Bruce P. Neuron . 2018,第6期

机译：通过皮质层5的电压依赖性电压控制轴突和体细胞静态潜力的差异控制
2. Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns. [J] . Broser P, Grinevich V, Osten P, Cerebral cortex . 2008,第7期

机译：大鼠体感皮层中2/3层锥体神经元轴突柄的关键时期可塑性：剥夺皮层的特定层投射减少。
3. Critical Period Plasticity of Axonal Arbors of Layer 2/3 Pyramidal Neurons in Rat Somatosensory Cortex: Layer-Specific Reduction of Projections into Deprived Cortical Columns [J] . P. Broser1 V. Grinevich23 P. Osten23 B. Sakmann1 and D. J. Wallace1 Cerebral Cortex . 2008,第7期

机译：大鼠体感皮层2/3层锥体神经元轴突轴的关键时期可塑性：剥皮皮质柱的投影的层特定减少。
4. Artificial neuron with somatic and axonal computation units: Mathematical and neuromorphic models of persistent firing neurons [C] . Ning Ning, Huang Kejie, Shi Luping Neural Networks (IJCNN), The 2012 International Joint Conference on . 2012

机译：具有躯体和轴突计算单元的人工神经元：持续激发神经元的数学和神经形态模型
5. Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances. [D] . Yamada-Hanff, Jason. 2015

机译：亚阈值电压依赖性电导调节海马锥体神经元兴奋性。
6. Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons [O] . Wenqin Hu, Bruce P. Bean -1

机译：皮层第5层锥体神经元中电压依赖性电导的轴突和体细胞静息电位的差分控制。
7. Critical period plasticity of axonal arbors of layer 2/3 pyramidal neurons in rat somatosensory cortex: layer-specific reduction of projections into deprived cortical columns [O] . Broser P., Grinevich V., Osten P., 2008

机译：大鼠体感皮层2/3层锥体神经元轴突柄的关键时期可塑性：剥夺皮层的特定层投影减少

Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons

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