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首页> 外文期刊>Neuron >Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay
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Task Demands Predict a Dynamic Switch in the Content of Awake Hippocampal Replay

机译：任务需求预测唤醒海马重播内容中的动态开关

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Summary Reactivation of hippocampal place cell sequences during behavioral immobility and rest has been linked with both memory consolidation and navigational planning. Yet it remains to be investigated whether these functions are temporally segregated, occurring during different behavioral states. During a self-paced spatial task, awake hippocampal replay occurring either immediately before movement toward a reward location or just after arrival at a reward location preferentially involved cells consistent with the current trajectory. In contrast, during periods of extended immobility, no such biases were evident. Notably, the occurrence of task-focused reactivations predicted the accuracy of subsequent spatial decisions. Additionally, during immobility, but not periods preceding or succeeding movement, grid cells in deep layers of the entorhinal cortex replayed coherently with the hippocampus. Thus, hippocampal reactivations dynamically and abruptly switch between operational modes in response to task demands, plausibly moving from a state favoring navigational planning to one geared toward memory consolidation. Highlights ? Place cell replay content varies between periods of task engagement and disengagement ? Upon arrival/before departure from reward sites, replay depicts task-relevant places ? No such bias was observed during periods of extended immobility ? Grid cells from deep MEC were coherent with place cells during extended stops ólafsdóttir et?al. found that, upon arrival at and before departure from reward sites, but not during immobility, hippocampal replay depicts places related to current task demands. Occurrence of task-focused replay predicts decision accuracy. Grid cells were only coherent with replay during immobility.
机译：总结在行为不动和休息期间的海马局部细胞序列的再激活已与内存整合和导航规划有关。然而，在不同的行为状态期间，它仍有待研究这些功能是否在时间上被隔离。在自定节奏的空间任务期间，在向奖励位置移动之前，唤醒海马重播，或者在奖励位置刚刚达到奖励位置，优先涉及与当前轨迹一致的细胞。相反，在延长的不动期期间，没有明显的这种偏见。值得注意的是，以任务为中心的重新激活的发生预测后续空间决策的准确性。另外，在不动期间，但是在前面或后续运动的不期间，Entorhinal皮质的深层的栅格细胞与海马连贯地重放。因此，响应于任务需求的操作模式动态地和突然切换的海马再激活，从有利于导航计划的状态移动到一个朝向存储器整合的状态。强调 ？ Place Cell Replay内容在任务啮合和脱离时段之间变化？抵达/离开前从奖励网站出发，重播描绘了相关的任务？在延长的不动期间没有观察到这种偏差？从深mec的栅格细胞在延长停止期间与地方细胞相干ólafsdóttir等。发现，在抵达和离开之前抵达奖励地点，但在不动期间，海马重播描述了与当前任务需求相关的地方。偏心重播的发生预测决策准确性。网格细胞在不动期间只能在重播中相干。

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