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The BRAIN Initiative Cell Census Consortium: Lessons Learned toward Generating a Comprehensive Brain Cell Atlas

机译:脑倡议细胞普查财团:学习朝向生成综合脑细胞阿特拉斯

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A comprehensive characterization of neuronal cell types, their distributions, and patterns of connectivity is critical for understanding the properties of neural circuits and how they generate behaviors. Here we review the experiences of the BRAIN Initiative Cell Census Consortium, ten pilot projects funded by the U.S. BRAIN Initiative, in developing, validating, and scaling up emerging genomic and anatomical mapping technologies for creating a complete inventory of neuronal cell types and their connections in multiple species and during development. These projects lay the foundation for a larger and longer-term effort to generate whole-brain cell atlases in species including mice and humans. In this Perspective, Ecker et?al. discuss the efforts of the BRAIN Initiative Cell Census Consortium, ten pilot projects whose collective goal was to develop and validate methods for generating comprehensive atlases of neuronal cell types in the mammalian brain.
机译:全面表征神经元细胞类型,它们的分布和连接模式对于了解神经电路的性质以及它们如何产生行为至关重要。 在这里,我们审查了由美国大脑倡议资助的大脑倡议细胞普查财团的经验,在开发,验证和扩大新出现的基因组和解剖学映射技术中,以创建内核细胞类型的完整库存及其联系 多种物种和发展期间。 这些项目奠定了较大和长期努力的基础,以在包括小鼠和人类在内的物种中产生全脑细胞联系。 在这个角度下,Ecker et?al。 讨论脑倡议细胞人口普查联盟的努力,该集体目标的十大试点项目是开发和验证在哺乳动物大脑中产生综合地图空间的方法。

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