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首页> 外文期刊>Neuron >Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents
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Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents

机译：动态erbb4在海马推职的同步和啮齿动物的全面关注

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摘要

Top-down attention is crucial for meaningful behaviors and impaired in various mental disorders. However, its underpinning regulatory mechanisms are poorly understood. We demonstrate that the hippocampal-prefrontal synchrony associates with levels of top-down attention. Both attention and synchrony are reduced in mutant mice of ErbB4, a receptor of neuregulin-1. We used chemical genetic and optogenetic approaches to inactivate ErbB4 kinase and ErbB4+ interneurons, respectively, both of which reduce gamma-aminobutyric acid (GABA) activity. Such inhibitions in the hippocampus impair both hippocampal-prefrontal synchrony and top-down attention, whereas those in the prefrontal cortex alter attention, but not synchrony. These observations identify a role of ErbB4-dependent GABA activity in the hippocampus in synchronizing the hippocampal-prefrontal pathway and demonstrate that acute, dynamic ErbB4 signaling is required to command top-down attention. Because both neuregulin-1 and ErbB4 are susceptibility genes of schizophrenia and major depression, our study contributes to a better understanding of these disorders. Video AbstractDisplay Omitted.
机译：自上而下的关注对于有意义的行为至关重要，并且在各种精神障碍中受损。然而，其支撑的监管机制很差。我们证明海马 - 前额相同步同步与全面关注的水平员工。在ErbB4的突变小鼠中，突变体小鼠，Neuregulin-1的受体的关注和同步都减少。我们使用化学遗传和致敏方法分别灭活ERBB4激酶和ERBB4 + Interneurons，两者都减少了γ-氨基丁酸（GABA）活性。海马中的这种抑制损害了海马前额相同步和全面的关注，而预选性皮质改变注意力，而不是同步。这些观察结果鉴定了在海马同步海马中ErbB4依赖性GABA活性的作用，并证明了急性，动态的ERBB4信令是指挥自上而下的关注。因为Neuregulin-1和Erbb4都是精神分裂症和重大抑郁症的易感基因，我们的研究有助于更好地了解这些障碍。 Video AbstractDisplay省略。

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  • 来源
    《Neuron》 |2018年第2期|共18页
  • 作者

    Zhibing Tan; Heath L. Robinson; Dong-Min Yin; Yu Liu; Fang Liu; Hongsheng Wang; Thiri W. Lin; Guanglin Xing; Lin Gan; Wen-Cheng Xiong; Lin Mei;

  • 作者单位

    Department of Neurosciences Case Western Reserve University School of Medicine Cleveland;

    Department of Neurosciences Case Western Reserve University School of Medicine Cleveland;

    Key Laboratory of Brain Functional Genomics Ministry of Education Shanghai Key Laboratory of;

    Department of Neuroscience and Regeneration Medicine Medical College of Georgia Augusta University;

    Department of Neuroscience and Regeneration Medicine Medical College of Georgia Augusta University;

    Department of Neurosciences Case Western Reserve University School of Medicine Cleveland;

    Department of Neuroscience and Regeneration Medicine Medical College of Georgia Augusta University;

    Department of Neurosciences Case Western Reserve University School of Medicine Cleveland;

    Department of Ophthalmology University of Rochester;

    Department of Neurosciences Case Western Reserve University School of Medicine Cleveland;

    Department of Neurosciences Case Western Reserve University School of Medicine Cleveland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

    ErbB4; neuregulin-1; hippocampal-prefrontal synchrony; top-down attention; GABA transmission; E/I balance; schizophrenia; major depression; ADHD;

    机译：erbb4;neuregulin-1;海马 - 前额相同步;全面关注;加巴传播;e / i平衡;精神分裂症;重大抑郁;adhd;

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