A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration

Federico W. Grillo; Guilherme Neves; Alison Walker; Gema Vizcay-Barrena; Roland A. Fleck; Tiago Branco; Juan Burrone

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A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration

机译：临时依赖性突触前围绕频率依赖性树突集成的分布

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How presynaptic inputs and neurotransmitter release dynamics are distributed along a dendritic tree is not well established. Here, we show that presynaptic boutons that form onto basal dendrites of CA1 pyramidal neurons display a decrease in active zone (AZ) size with distance from the soma, resulting in a distance-dependent increase in short-term facilitation. Our findings suggest that the spatial distribution of short-term facilitation serves to compensate for the?electrotonic attenuation of subthreshold distal inputs during repeated stimulation and fine-tunes the preferred input frequency of dendritic domains.

机译：突触前输入和神经递质释放动力学如何沿树突树分布并不确定。在这里，我们表明，形成在Ca1金字塔神经元的基底树枝状曲线上的突触前Boutons在距离SOMA的距离下显示有源区（AZ）尺寸的减少，从而导致短期促进的距离依赖性增加。我们的研究结果表明，短期促进的空间分布用于补偿亚阈值远端输入期间的亚阈值远端输入的电验衰减，并进行细长的树突域的优选输入频率。

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来源
《Neuron》 |2018年第2期|共8页
作者
Federico W. Grillo; Guilherme Neves; Alison Walker; Gema Vizcay-Barrena; Roland A. Fleck; Tiago Branco; Juan Burrone;
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作者单位

Centre for Developmental Neurobiology Kings College London Guys Hospital Campus;

Centre for Developmental Neurobiology Kings College London Guys Hospital Campus;

Centre for Developmental Neurobiology Kings College London Guys Hospital Campus;

Centre for Ultrastructural Imaging (CUI) Kings College London Guys Hospital Campus;

Centre for Ultrastructural Imaging (CUI) Kings College London Guys Hospital Campus;

The Sainsbury Wellcome Centre University College London;

Centre for Developmental Neurobiology Kings College London Guys Hospital Campus;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词
presynaptic terminal; short-term plasticity; dendritic integration; synaptic transmission; release probability; active zone; hippocampus;

机译：突触前终端;短期可塑性;树突整合;突触传递;释放概率;有源区;海马;

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专利

1. A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration [J] . Federico W. Grillo, Guilherme Neves, Alison Walker, Neuron . 2018,第2期

机译：临时依赖性突触前围绕频率依赖性树突集成的分布
2. Dynamics of dendritic spines and their afferent terminals: spines are more motile than presynaptic boutons ☆ [J] . Jinbo Deng, Anna Dunaevsky Developmental biology . 2005,第2期

机译：树突棘及其传入终末的动力学：棘突比突触前的运动更活跃☆
3. Distribution and dynamics of synaptic proteins in presynaptic boutons induced on micropatterned host substrate [J] . Nosov G., Trache J., Glyvuk N., The FEBS journal . 2017,第Suppla1期

机译：突触前宿主底物诱导突触前突触蛋白的分布与动态
4. Simulation of Neurotransmitter Flow in Three Dimensional Model of Presynaptic Bouton [C] . Andrzej Bielecki, Maciej Gierdziewicz International Conference on Computational Science . 2020

机译：突触前布顿三维模型中神经递质流动的模拟
5. Fine-tuning Synaptic Plasticity by Modulation of Presynaptic Calcium(V)2.1 Channels with Calcium(II) Sensor Proteins. [D] . Leal, Karina. 2012

机译：通过调节钙（II）传感器蛋白的突触前钙（V）2.1通道微调突触可塑性。
6. A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration [O] . Federico W. Grillo, Guilherme Neves, Alison Walker, -1

机译：突触前钮扣的距离相关分布调整了频率相关的树突整合。
7. Dynamics of dendritic spines and their afferent terminals: spines are more motile than presynaptic boutons [O] . Deng Jinbo, Dunaevsky Anna 2005

机译：树突棘及其传入终末的动力学：棘突比突触前的运动更活跃

A Distance-Dependent Distribution of Presynaptic Boutons Tunes Frequency-Dependent Dendritic Integration

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