Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

VanRyzin Jonathan W.; Marquardt Ashley E.; Argue Kathryn J.; Vecchiarelli Haley A.; Ashton Sydney E.; Arambula Sheryl E.; Hill Matthew N.; McCarthy Margaret M.

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Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

机译：新生儿细胞的小胶质吞噬作用是由Endocannabinoids诱导的少年大鼠社会戏剧中的性别差异

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Brain sex differences are established developmentally and generate enduring changes in circuitry and behavior. Steroid-mediated masculinization of the rat amygdala during perinatal development produces higher levels of juvenile rough-and-tumble play by males. This sex difference in social play is highly conserved across mammals, yet the mechanisms by which it is established are unknown. Here, we report that androgen-induced increases in endocannabinoid tone promote microglia phagocytosis during a critical period of amygdala development. Phagocytic microglia engulf more viable newborn cells in males; in females, less phagocytosis allows more astrocytes to survive to the juvenile age. Blocking complement-dependent phagocytosis in males increases astrocyte survival and prevents masculinization of play. Moreover, increased astrocyte density in the juvenile amygdala reduces neuronal excitation during play. These findings highlight novel mechanisms of brain development whereby endocannabinoids induce microglia phagocytosis to regulate newborn astrocyte number and shape the sexual differentiation of social circuitry and behavior.

机译：脑性别差异是在发展的发展中建立并产生持久的电路和行为变化。类动物介导的大鼠氨基幼虫在围产期发育过程中的阳性化产生较高水平的男性幼儿粗糙和翻滚。这种社会游戏的性别差异在哺乳动物中高度保守，但建立的机制是未知的。在这里，我们报告了雄激素诱导的雄激素诱导的内炎素骨髓调高，促进了在Amygdala发育的关键期间的微胶质吞噬作用。吞噬细胞吞噬更可行的男性新生儿细胞;在女性中，少吞噬作用允许更多的星形胶质细胞生存到少年时代。阻断男性中的补充依赖性吞噬作用增加了星形胶质细胞存活率并防止阳性化的阳性化。此外，少年杏仁达拉中的星形胶质细胞密度增加减少了在比赛中的神经元励磁。这些发现突出了大脑发育的新机制，其中内胆蛋白诱导微脊布吞噬作用，以调节新生儿星形胶质细胞数，塑造社会电路和行为的性分化。

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《Neuron》 |2019年第2期|共21页
作者
VanRyzin Jonathan W.; Marquardt Ashley E.; Argue Kathryn J.; Vecchiarelli Haley A.; Ashton Sydney E.; Arambula Sheryl E.; Hill Matthew N.; McCarthy Margaret M.;
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Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Univ Maryland Sch Med Dept Pharmacol Baltimore MD 21201 USA;

Univ Calgary Cumming Sch Med Hotchkiss Brain Inst Calgary AB T2N 4N1 Canada;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

Univ Maryland Sch Med Dept Pharmacol Baltimore MD 21201 USA;

Univ Calgary Cumming Sch Med Hotchkiss Brain Inst Calgary AB T2N 4N1 Canada;

Univ Maryland Sch Med Program Neurosci Baltimore MD 21201 USA;

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正文语种 eng
中图分类神经病学;
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1. Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play [J] . VanRyzin Jonathan W., Marquardt Ashley E., Argue Kathryn J., Neuron . 2019,第2期

机译：新生儿细胞的小胶质吞噬作用是由Endocannabinoids诱导的少年大鼠社会戏剧中的性别差异
2. DYNAMIC CHANGES IN EXTRACELLULAR RELEASE OF GABA AND GLUTAMATE IN THE LATERAL SEPTUM DURING SOCIAL PLAY BEHAVIOR IN JUVENILE RATS: IMPLICATIONS FOR SEX-SPECIFIC REGULATION OF SOCIAL PLAY BEHAVIOR [J] . Bredewold R., Schiavo J. K., van der Hart M., Neuroscience: An International Journal under the Editorial Direction of IBRO . 2015,第Null期

机译：幼年大鼠社交游戏行为过程中横向皮脂中GABA和谷氨酸盐胞外释放的动态变化：对社交游戏行为的性别特异性调节的意义
3. Mean girls: Sex differences in the effects of mild traumatic brain injury on the social dynamics of juvenile rat play behaviour [J] . MychasiukR., HeharH., FarranA., Behavioural Brain Research: An International Journal . 2014,第Null期

机译：中等女孩：轻度脑外伤对少年大鼠游戏行为社会动态影响的性别差异
4. Sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells [C] . Gonzalez Rodolfo, Gomis-Tena Julio, Corrias Alberto, 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：在减少的复极储备下模拟心室细胞中多美特利在药物诱导的QT延长中与性别和年龄相关的差异
5. Complement Protein C1q: an Immunological Rheostat That Sculpts the Innate and Adaptive Immune Response During the Phagocytosis of Dying Cells. [D] . Clarke, Elizabeth Victoria. 2014

机译：补体蛋白C1q：一种免疫变阻剂，可在吞噬细胞吞噬过程中雕刻出先天性和适应性免疫反应。
6. Dynamic changes in extracellular release of GABA and glutamate in the lateral septum during social play behavior in juvenile rats: Implications for sex-specific regulation of social play behavior [O] . Remco Bredewold, Jennifer K. Schiavo, Marieke van der Hart, -1

机译：幼年大鼠社交游戏行为中外侧隔中GABA和谷氨酸胞外释放的动态变化：对社交游戏行为的性别特异性调节的意义
7. Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play [O] . Jonathan W. VanRyzin, Ashley E. Marquardt, Kathryn J. Argue, 2019

机译：新生儿细胞的小胶质吞噬作用是由环纳蟾蜍诱导的少年大鼠社会戏剧诱导性别差异

Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

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