Reversible Inactivation of Different Millimeter-Scale Regions of Primate IT Results in Different Patterns of Core Object Recognition Deficits

Rajalingham Rishi; DiCarlo James J.

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Reversible Inactivation of Different Millimeter-Scale Regions of Primate IT Results in Different Patterns of Core Object Recognition Deficits

机译：可逆毫米级别的灵长类动物区的灭活它导致不同的核心物体识别缺陷模式

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Extensive research suggests that the inferior temporal (IT) population supports visual object recognition behavior. However, causal evidence for this hypothesis has been equivocal, particularly beyond the specific case of face-selective subregions of IT. Here, we directly tested this hypothesis by pharmacologically inactivating individual, millimeter-scale subregions of IT while monkeys performed several core object recognition subtasks, interleaved trial-by trial. First, we observed that IT inactivation resulted in reliable contralateral-biased subtask-selective behavioral deficits. Moreover, inactivating different IT subregions resulted in different patterns of subtask deficits, predicted by each subregion's neuronal object discriminability. Finally, the similarity between different inactivation effects was tightly related to the anatomical distance between corresponding inactivation sites. Taken together, these results provide direct evidence that the IT cortex causally supports general core object recognition and that the underlying IT coding dimensions are topographically organized.

机译：广泛的研究表明，较低的时间（IT）群体支持视觉对象识别行为。然而，这一假设的因果证据已经确定，特别是超越了它的面部选择性次区域的具体情况。在这里，我们通过药理学灭活的个体，IT的毫米级次区域直接测试了这一假设，而猴子执行了几个核心对象识别子任务，则交错试验。首先，我们观察到它失活导致对侧偏置的副席位选择性行为赤字可靠。此外，灭活不同的IT子区域导致由每个子区域的神经元对象辨别性预测的子批次缺陷的不同模式。最后，不同的灭活效应之间的相似性与相应的灭活位点之间的解剖距离紧密相关。总之，这些结果提供了直接证据表明IT皮质因果支持一般核心对象识别，并且潜在的IT编码尺寸是拓扑结构的。

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《Neuron》 |2019年第2期|共18页
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Rajalingham Rishi; DiCarlo James J.;
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MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA;

MIT McGovern Inst Brain Res 77 Massachusetts Ave Cambridge MA 02139 USA;

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正文语种 eng
中图分类神经病学;
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1. Reversible Inactivation of Different Millimeter-Scale Regions of Primate IT Results in Different Patterns of Core Object Recognition Deficits [J] . Rajalingham Rishi, DiCarlo James J. Neuron . 2019,第2期

机译：可逆毫米级别的灵长类动物区的灭活它导致不同的核心物体识别缺陷模式
2. A network view on brain regions involved in experts' object and pattern recognition: Implications for the neural mechanisms of skilled visual perception [J] . Langner Robert, Eickhoff Simon B., Bilalic Merim Brain and cognition . 2019,第APRa期

机译：涉及专家对象和模式识别的大脑区域的网络视图：对熟练的视觉感知的神经机制的启示
3. A network view on brain regions involved in experts' object and pattern recognition: Implications for the neural mechanisms of skilled visual perception [J] . Langner Robert, Eickhoff Simon B., Bilalic Merim Brain and cognition . 2019,第Apra期

机译：关于专家对象和模式识别的脑区网络视图：对熟练的视觉感知神经机制的影响
4. Pattern recognition attention and information bottlenecks in the primate visual system [C] . David Van Essen, California Institute of Technology, Pasadena, Visual Information Processing: From Neurons to Chips . 1991

机译：灵长类视觉系统中的模式识别注意和信息瓶颈
5. Reversible Inactivation of the Dorsolateral Prefrontal Cortex in Non- Human Primates via Designer Receptors Exclusively Activated by Designer Drugs Impairs a Spatial Memory Task [D] . Schnebelen, Wendy 2015

机译：通过设计药物独家激活的设计受体使非人类灵长类动物的前外侧前额叶皮层可逆失活会损害空间记忆任务。
6. Post-training reversible inactivation of the hippocampus enhances novel object recognition memory [O] . Ana M.M. Oliveira, Joshua D. Hawk, Ted Abel, 2010

机译：训练后海马的可逆失活增强了新的对象识别记忆
7. Reversible inactivation of different millimeter-scale regions of primate IT results in different patterns of core object recognition deficits [O] . Rishi Rajalingham, James J. DiCarlo 2018

机译：可逆毫米级别的灵长类动物区域的逆动导致核心物体识别缺陷的不同模式

Reversible Inactivation of Different Millimeter-Scale Regions of Primate IT Results in Different Patterns of Core Object Recognition Deficits

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