...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Alcohol Activates Scabrous-Notch to Influence Associated Memories
【24h】

Alcohol Activates Scabrous-Notch to Influence Associated Memories

机译：酒精激活舒适的缺口以影响相关的记忆

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Drugs of abuse, like alcohol, modulate gene expression in reward circuits and consequently alter behavior. However, the in vivo cellular mechanisms through which alcohol induces lasting transcriptional changes are unclear. We show that Drosophila Notch/Su(H) signaling and the secreted fibrino-genrelated protein Scabrous in mushroom body (MB) memory circuitry are important for the enduring preference of cues associated with alcohol's rewarding properties. Alcohol exposure affects Notch responsivity in the adult MB and alters Su(H) targeting at the dopamine-2-like receptor (Dop2R). Alcohol cue training also caused lasting changes to the MB nuclear transcriptome, including changes in the alternative splicing of Dop2R and newly implicated transcripts like Stat92E. Together, our data suggest that alcohol-induced activation of the highly conserved Notch pathway and accompanying transcriptional responses in memory circuitry contribute to addiction. Ultimately, this provides mechanistic insight into the etiology and pathophysiology of alcohol use disorder.
机译：滥用药物，如酒精，调节奖励电路中的基因表达，从而改变行为。然而，体内细胞机制通过哪种酒精诱导持久转录变化尚不清楚。我们表明果蝇Notch / Su（h）信号传导和分泌的纤维族酸化蛋白在蘑菇体（MB）存储器电路中酸酸酸槽是重要的，对于与酒精有益的性质相关的提示的持久偏好是重要的。酒精暴露会影响成体MB中的缺口响应率，并在多巴胺-2样受体（DOP2R）上靶向靶向SU（H）。酒精提示培训也对MB核转录组产生了持久的变化，包括DOP2R的替代剪接和新涉及STAT92E等新涉及的转录物的变化。我们的数据表明，酒精诱导的高度保守的陷波途径激活并随附记忆电路中的转录反应有助于成瘾。最终，这为机械深入了解酒精使用障碍的病因和病理生理学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号