The Tau of Nuclear-Cytoplasmic Transport

Evan Lester; Roy Parker

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The Tau of Nuclear-Cytoplasmic Transport

机译：核 - 细胞质交通的陶

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摘要

Aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including Alzheimer’s disease. demonstrate that pathogenic tau alters nucleocytoplasmic transport by interacting with components of the nuclear pore complex, revealing a perturbation shared by multiple neurodegenerative diseases.

机译：微管相关蛋白Tau的聚集是托针的标志，包括阿尔茨海默病。证明致病性Tau通过与核孔隙复合物的组分相互作用而改变核细胞质运输，揭示了多种神经变性疾病共享的扰动。

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《Neuron》 |2018年第5期|共3页
作者
Evan Lester; Roy Parker;
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作者单位

Department of Biochemistry University of Colorado;

Department of Biochemistry University of Colorado;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
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专利

1. The Tau of Nuclear-Cytoplasmic Transport [J] . Evan Lester, Roy Parker Neuron . 2018,第5期

机译：核 - 细胞质交通的陶
2. Nicotiana benthamiana RanBP1-1 Is Involved in the Induction of Disease Resistance via Regulation of Nuclear-Cytoplasmic Transport of Small GTPase Ran [J] . Yuri Mizuno, Mina Ohtsu, Yusuke Shibata, Frontiers in Plant Science . 2019,第1期

机译： Nicotiana benthamiana RanBP1-1参与通过调节小GTPase Ran的细胞质胞质转运来诱导抗病性
3. Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis [J] . Yan Dongqing, Pomicter Anthony D., Tantravahi Srinivas, Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第7期

机译：核 - 细胞质运输是髓纤维化的治疗靶标
4. Regulation of the human taurine transporter by TNF-a and an anti-inflammatory function of taurine in human intestinal Caco-2 cells [C] . Tetsunosuke Mochizuki, Hideo Satsu, Tomoko Nakano, International Conference on Food Factors . 2004

机译：通过TNF-A和人肠道Caco-2细胞的牛磺酸的抗炎功能调节人牛磺酸转运蛋白
5. The N-terminus of tau in filament formation and the regulation of axonal transport: A perspective on tau assembly and toxicity. [D] . LaPointe, Nichole E. M. 2008

机译：tau在细丝形成中的N末端和轴突运输的调节：关于tau组装和毒性的观点。
6. Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway [O] . Shoko Saito, Sadik Cigdem, Mitsuru Okuwaki, 2016

机译：白血病相关的Nup214融合蛋白干扰XPO1介导的核细胞质运输途径从而干扰NF-κB信号传导途径。
7. Phospho-Tau Impairs Nuclear-Cytoplasmic Transport [O] . Timir Tripathi, Jay Prakash, Yaron Shav-Tal 2018

机译：磷脂损害核 - 细胞质运输
8. High Affinity Transport of Taurine and beta-Alanine and Low Affinity Transport gamma-Aminobutyric Acid by a Single Transport System in Cultured Glioma Cells. [R] . Martin, D. L., Shain, W. 1978

机译：通过单一转运系统在培养的神经胶质瘤细胞中高亲和力转运牛磺酸和β-丙氨酸以及低亲和力转运γ-氨基丁酸。

The Tau of Nuclear-Cytoplasmic Transport

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