High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays

Chung Jason E.; Joo Hannah R.; Fan Jiang Lan; Liu Daniel F.; Barnett Alex H.; Chen Supin; Geaghan-Breiner Charlotte; Karlsson Mattias P.; Karlsson Magnus; Lee Kye Y.; Liang Hexin; Magland Jeremy F.; Pebbles Jeanine A.; Tooker Angela C.; Greengard Leslie F.; Tolosa Vanessa M.; Frank Loren M.

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High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays

机译：使用聚合物电极阵列的高密度，长持久和多区域电生理记录

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The brain is a massive neuronal network, organized into anatomically distributed sub-circuits, with functionally relevant activity occurring at timescales ranging from milliseconds to years. Current methods to monitor neural activity, however, lack the necessary conjunction of anatomical spatial coverage, temporal resolution, and long-term stability to measure this distributed activity. Here we introduce a largescale, multi-site, extracellular recording platform that integrates polymer electrodes with a modular stacking headstage design supporting up to 1,024 recording channels in freely behaving rats. This system can support months-long recordings from hundreds of well-isolated units across multiple brain regions. Moreover, these recordings are stable enough to track large numbers of single units for over a week. This platform enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale evolution of anatomically distributed circuits, and thereby provides a new tool for understanding brain activity.

机译：大脑是一种巨大的神经元网络，组织到解剖学分布的子电路中，功能上有相关的活动，在时间尺寸的时间内发生。然而，监测神经活动的目前的方法缺乏解剖空间覆盖，时间分辨率和长期稳定性来测量该分布活动的必要结合。在这里，我们介绍了一种庞大的尺寸，多场的细胞外记录平台，将聚合物电极与模块化堆叠镦颈裤设计集成，其在自由行为大鼠中高达1,024个记录通道。该系统可以在多个大脑区域的数百个孤立的单位中支持几个月的录音。此外，这些录音足够稳定，可以追踪一周多的单位单位。该平台使大规模电生理询问的快速动力学和远期分布式电路的长时间演变，从而为理解大脑活动提供了一种新工具。

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《Neuron》 |2019年第1期|共16页
作者
Chung Jason E.; Joo Hannah R.; Fan Jiang Lan; Liu Daniel F.; Barnett Alex H.; Chen Supin; Geaghan-Breiner Charlotte; Karlsson Mattias P.; Karlsson Magnus; Lee Kye Y.; Liang Hexin; Magland Jeremy F.; Pebbles Jeanine A.; Tooker Angela C.; Greengard Leslie F.; Tolosa Vanessa M.; Frank Loren M.;
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作者单位

Univ Calif San Francisco Med Scientist Training Program San Francisco CA 94158 USA;

Univ Calif San Francisco Med Scientist Training Program San Francisco CA 94158 USA;

Univ Calif San Francisco Bioengn Grad Program San Francisco CA 94158 USA;

Univ Calif San Francisco Ctr Integrat Neurosci Kavli Inst Fundamental Neurosci San Francisco CA;

Flatiron Inst Ctr Computat Biol 162 Fifth Ave New York NY 10010 USA;

Lawrence Livermore Natl Lab Ctr Micro &

Nano Technol Livermore CA 94550 USA;

Univ Calif San Francisco Ctr Integrat Neurosci Kavli Inst Fundamental Neurosci San Francisco CA;

SpikeGadgets LLC San Francisco CA 94158 USA;

SpikeGadgets LLC San Francisco CA 94158 USA;

Lawrence Livermore Natl Lab Ctr Micro &

Nano Technol Livermore CA 94550 USA;

Univ Calif San Francisco Ctr Integrat Neurosci Kavli Inst Fundamental Neurosci San Francisco CA;

Flatiron Inst Ctr Computat Biol 162 Fifth Ave New York NY 10010 USA;

Lawrence Livermore Natl Lab Ctr Micro &

Nano Technol Livermore CA 94550 USA;

Lawrence Livermore Natl Lab Ctr Micro &

Nano Technol Livermore CA 94550 USA;

Flatiron Inst Ctr Computat Biol 162 Fifth Ave New York NY 10010 USA;

Lawrence Livermore Natl Lab Ctr Micro &

Nano Technol Livermore CA 94550 USA;

Univ Calif San Francisco Ctr Integrat Neurosci Kavli Inst Fundamental Neurosci San Francisco CA;

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正文语种 eng
中图分类神经病学;
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专利

1. High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays [J] . Chung Jason E., Joo Hannah R., Fan Jiang Lan, Neuron . 2019,第1期

机译：使用聚合物电极阵列的高密度，长持久和多区域电生理记录
2. Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays (vol 13, pg 965, 2018) [J] . Dipalo Michele, Melle Giovanni, Lovato Laura, Nature nanotechnology . 2018,第10期

机译：等离子体元电极允许在高密度CMOS - 多电极阵列上的网络电平的细胞内记录（Vol 13，PG 965,2018）
3. Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays [J] . Dipalo Michele, Melle Giovanni, Lovato Laura, Nature nanotechnology . 2018,第10期

机译：等离子体元电极允许在高密度CMOS - 多电极阵列上的网络电平的细胞内记录
4. Chronic Multi-Region Recording from the Rat Hippocampus in vivo with a Flexible Parylene-Based Multi-Electrode Array [C] . Huijing Xu, Ahuva Weltman, Kee Scholten, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

机译：Vivo大鼠海马的慢性多区域记录，具有柔性基于聚偶烯的多电极阵列
5. Neural Interfacing with Dorsal Root Ganglia: Anatomical Characterization and Electrophysiological Recordings with Novel Electrode Arrays [D] . Sperry, Zachariah. 2019

机译：具有背根神经节的神经界面：具有新型电极阵列的解剖学表征和电生理学记录
6. Acute in vivo testing of a conformal polymer microelectrode array for multi-region hippocampal recordings [O] . Huijing Xu, Ahuva Weltman Hirschberg, Kee Scholten, -1

机译：保形聚合物微电极阵列在多区域海马记录中的急性体内测试
7. High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays [O] . Jason E. Chung, Hannah R. Joo, Jiang Lan Fan, 2019

机译：使用聚合物电极阵列的高密度，长持久和多区域电生理记录
8. Miniaturized High-Density Multichannel Electrode Array for Long-Term Neuronal Recordings. [R] . Nicolelis, M. A. L., Lehew, G. C., Krupa, D. J. 2005

机译：用于长期神经元记录的小型化高密度多通道电极阵列。

High-Density, Long-Lasting, and Multi-region Electrophysiological Recordings Using Polymer Electrode Arrays

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