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首页> 外文期刊>Neuropharmacology >Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke
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Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke

机译：α-亚麻酸作为肠内或肠胃外营养干预的缺血性卒中小鼠模型中的肠内或肠胃外营养干预和认知缺陷

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摘要

Stroke is a leading cause of disability and death worldwide. Numerous therapeutics applied acutely after stroke have failed to improve long-term clinical outcomes. An emerging direction is nutritional intervention with omega-3 polyunsaturated fatty acids acting as disease-modifying factors and targeting post-stroke disabilities. Our previous studies demonstrated that the omega-3 precursor, alpha-linolenic acid (ALA) administrated by injections or dietary supplementation reduces stroke damage by direct neuroprotection, and triggering brain artery vasodilatation and neuroplasticity. Successful translation of putative therapies will depend on demonstration of robust efficacy on common deficits resulting from stroke like loss of motor control and memory/learning. This study evaluated the value of ALA as adjunctive therapy for stroke recovery by comparing whether oral or intravenous supplementation of ALA best support recovery from ischemia. Motor and cognitive deficits were assessed using rotarod, pole and Morris water maze tests. ALA supplementation in diet was better than intravenous treatment in improving motor coordination, but this improvement was not due to a neuroprotective effect since infarct size was not reduced. Both types of ALA supplementation improved spatial learning and memory after stroke. This cognitive improvement correlated with higher survival of hippocampal neurons. These results support clinical investigation establishing therapeutic plans using ALA supplementation. (C) 2016 The Authors. Published by Elsevier Ltd.
机译：中风是全世界残疾和死亡的主要原因。卒中后急性施用的许多治疗剂未能改善长期临床结果。新出现的方向是营养干预，欧米茄-3多不饱和脂肪酸作用为疾病改性因子和靶向后抚扰性残疾。我们以前的研究表明，通过注射或膳食补充剂给予ω-3前体，α-亚麻酸（ALA）通过直接神经保护和触发脑动脉血管扩张和神经塑性来减少中风损伤。成功的推定疗法翻译将取决于对常见缺陷的稳健效率的证明，这是由电机控制和记忆/学习的损失造成的常见缺陷。该研究通过比较了是否从缺血中的最佳支持恢复是最佳的支持恢复，评估ALA作为中风恢复的辅助治疗的价值。使用旋转线，杆和莫里斯水迷宫测试评估电机和认知缺陷。 ALA补充饮食优于静脉注射治疗改善电机协调，但由于梗塞尺寸未降低，这种改善不是由于神经保护作用。两种类型的ALA补充在中风后改善了空间学习和记忆。这种认知改善与海马神经元的较高存活相关。这些结果支持使用ALA补充建立治疗计划的临床调查。 （c）2016年作者。 elsevier有限公司出版

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