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首页> 外文期刊>Neuropsychology >Patients With Parkinson's Disease Display a Dopamine Therapy Related Negative Bias and an Enlarged Range in Emotional Responses to Facial Emotional Stimuli
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Patients With Parkinson's Disease Display a Dopamine Therapy Related Negative Bias and an Enlarged Range in Emotional Responses to Facial Emotional Stimuli

机译：帕金森病的患者展示了多巴胺治疗相关的负面偏差和对面部情感刺激的情绪反应的扩大范围

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Objective: The literature on emotional processing in Parkinson's disease (PD) patients shows mixed results. This may be because of various methodological and/or patient-related differences, such as failing to adjust for cognitive functioning, depression, and/or mood. Method: In the current study, we tested PD patients and healthy controls (HCs) using emotional stimuli across a variety of tasks, including visual search, short-term memory (STM), categorical perception, and emotional stimulus rating. The PD and HC groups were matched on cognitive ability, depression, and mood. We also explored possible relationships between task results and antiparkinsonian treatment effects, as measured by levodopa equivalent dosages (LED), in the PD group. Results: The results show that PD patients use a larger emotional range compared with HCs when reporting their impression of emotional faces on rated emotional valence, arousal, and potency. The results also show that dopaminergic therapy was correlated with stimulus rating results such that PD patients with higher LED scores rated negative faces as less arousing, less negative, and less powerful. Finally, results also show that PD patients display a general slowing effect in the visual search tasks compared with HCs, indicating overall slowed responses. There were no group differences observed in the STM or categorical perception tasks. Conclusions: Our results indicate a relationship between emotional responses, PD, and dopaminergic therapy, in which PD per se is associated with stronger emotional responses, whereas LED levels are negatively correlated with the strength of emotional responses.
机译：目的：帕金森病（PD）患者情绪加工的文献显示出混合结果。这可能是因为各种方法和/或患者相关的差异，例如未能调整认知功能，抑郁和/或情绪。方法：在目前的研究中，我们在各种任务中使用情感刺激测试了PD患者和健康控制（HCS），包括视觉搜索，短期记忆（STM），分类感知和情绪刺激等级。 Pd和HC组与认知能力，抑郁和情绪相匹配。我们还探讨了任务结果与抗原蛋白酶治疗效果之间的可能关系，如PD组中的左旋多巴等效剂量（LED）测量。结果：结果表明，当报告其对额定情绪化的情绪，唤醒和效力时，PD患者与HCS相比使用较大的情绪范围。结果还表明，多巴胺能治疗与刺激评级结果相关，使得LED较高的PD患者分数额定阴性面值较少，较少，负面，更强大。最后，结果还表明，与HCS相比，PD患者在视觉搜索任务中显示了一般放缓效果，表明整体减缓了响应。在STM或分类的感知任务中没有观察到群体差异。结论：我们的结果表明情绪反应，Pd和多巴胺能治疗之间的关系，其中Pd本身与更强的情绪反应相关，而LED水平与情绪反应的强度负相关。

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