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首页> 外文期刊>Neuropsychology >Longitudinal Intra-Individual Variability in Neuropsychological Performance Relates to White Matter Changes in HIV
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Longitudinal Intra-Individual Variability in Neuropsychological Performance Relates to White Matter Changes in HIV

机译：神经心理学性能的纵向个体变异性涉及艾滋病毒的白质变性

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Objectives: Recent studies suggest that intraindividual variability (IIV) of neuropsychological performance may be sensitive to HIV-associated neurologic compromise. IIV may be particularly dependent upon the integrity of frontal-subcortical systems, and therefore may be a meaningful phenotype in HIV. We examined the relationship between change in IIV and white matter integrity among HIV seropositive (HIV+) and HIV seronegative (HIV-) individuals. Method: The sample consisted of 38 HIV+ participants and 26 HIV- control participants who underwent neuroimaging and a neuropsychological evaluation at baseline and at 2-year follow-up evaluation. Results: Among HIV+ participants, increases in IIV (greater dispersion) were related to lower fractional anisotropy (FA) values in the anterior thalamic radiations (ATR) and the superior longitudinal fasciculus (SLF). Changes in mean-level global cognitive functioning were not significantly related to white matter integrity. Additionally, there was a significant Group x IIV interaction effect in the SLF demonstrating that the relationship between IIV and white matter integrity was specific to HIV. Conclusions: Overall, findings suggest that IIV may be more sensitive, relative to mean-level global cognitive functioning, in the detection of neurologic compromise among HIV+ individuals.
机译：目的：最近的研究表明，神经心理学性能的闭合性变异性（IIV）可能对艾滋病毒相关的神经系统妥协敏感。 IIV可能特别依赖于额外解性系统的完整性，因此可能是艾滋病毒中有意义的表型。我们研究了艾滋病毒血清阳性（HIV +）和HIV血清（HIV-）个体之间的IIV和白质完整性之间的关系。方法：该样品由38名艾滋病毒+参与者和26名艾滋病毒控制参与者组成，在基线和2年的后续评估中接受神经影像动物和神经心理学评估。结果：在艾滋病毒+参与者中，IIV（更大的分散）的增加与前丘脑辐射（ATR）和优异的纵向束（SLF）中的较低分数各向异性（FA）值有关。平均全球认知功能的变化与白质完整性没有显着相关。另外，SLF中存在显着的X IIV相互作用效果，证明了IIV和白质完整性之间的关系是特异于HIV。结论：总体而言，研究表明，在艾滋病毒+个体中，IIV可能更敏感，相对于平均全球认知功能，在检测HIV +个体中的神经系统折衷中。

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